Ribonuclease Inhibitor and Angiogenin System Regulates Cell Type-specific Global Translation

Overview

Journal Sci Adv

Specialties Biology
Science

Date 2024 May 31

PMID 38820160

Authors

Martina Stillinovic

Mayuresh Anant Sarangdhar

Nicola Andina

Aubry Tardivel

Frederic Greub

Giuseppe Bombaci

Camille Ansermet

Marco Zatti

Dipanjali Saha

Jieyu Xiong

Takeru Sagae

Mariko Yokogawa

Masanori Osawa

Manfred Heller

Adrian Keogh

Irene Keller

Anne Angelillo-Scherrer

Ramanjaneyulu Allam

Affiliations

Soon will be listed here.

Abstract

Translation of mRNAs is a fundamental process that occurs in all cell types of multicellular organisms. Conventionally, it has been considered a default step in gene expression, lacking specific regulation. However, recent studies have documented that certain mRNAs exhibit cell type-specific translation. Despite this, it remains unclear whether global translation is controlled in a cell type-specific manner. By using human cell lines and mouse models, we found that deletion of the ribosome-associated protein ribonuclease inhibitor 1 (RNH1) decreases global translation selectively in hematopoietic-origin cells but not in the non-hematopoietic-origin cells. RNH1-mediated cell type-specific translation is mechanistically linked to angiogenin-induced ribosomal biogenesis. Collectively, this study unravels the existence of cell type-specific global translation regulators and highlights the complex translation regulation in vertebrates.

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