Adrian J Jervis
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Explore the profile of Adrian J Jervis including associated specialties, affiliations and a list of published articles.
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28
Citations
571
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Recent Articles
1.
Hanko E, Robinson C, Bhanot S, Jervis A, Scrutton N
Microb Cell Fact
. 2024 Nov;
23(1):312.
PMID: 39558341
Background: Flavonoids are a structurally diverse group of secondary metabolites, predominantly produced by plants, which include a range of compounds with pharmacological importance. Pinocembrin is a key branch point intermediate...
2.
Robinson C, Tellechea-Luzardo J, Carbonell P, Jervis A, Yan C, Hollywood K, et al.
Biochem Soc Trans
. 2021 Jun;
49(3):1055-1063.
PMID: 34100907
Metabolic engineering technologies have been employed with increasing success over the last three decades for the engineering and optimization of industrial host strains to competitively produce high-value chemical targets. To...
3.
A plasmid toolset for CRISPR-mediated genome editing and CRISPRi gene regulation in Escherichia coli
Jervis A, Hanko E, Dunstan M, Robinson C, Takano E, Scrutton N
Microb Biotechnol
. 2021 Mar;
14(3):1120-1129.
PMID: 33710766
CRISPR technologies have become standard laboratory tools for genetic manipulations across all kingdoms of life. Despite their origins in bacteria, the development of CRISPR tools for engineering bacteria has been...
4.
Dunstan M, Robinson C, Jervis A, Yan C, Carbonell P, Hollywood K, et al.
Synth Biol (Oxf)
. 2020 Nov;
5(1):ysaa012.
PMID: 33195815
Natural plant-based flavonoids have drawn significant attention as dietary supplements due to their potential health benefits, including anti-cancer, anti-oxidant and anti-asthmatic activities. Naringenin, pinocembrin, eriodictyol and homoeriodictyol are classified as...
5.
Barnawi H, Masri N, Hussain N, Al-Lawati B, Mayasari E, Gulbicka A, et al.
PLoS Pathog
. 2020 Oct;
16(10):e1009008.
PMID: 33064782
RNA thermometers (RNATs) trigger bacterial virulence factor expression in response to the temperature shift on entering a warm-blooded host. At lower temperatures these secondary structures sequester ribosome-binding sites (RBSs) to...
6.
Currin A, Swainston N, Dunstan M, Jervis A, Mulherin P, Robinson C, et al.
Synth Biol (Oxf)
. 2020 Sep;
4(1):ysz025.
PMID: 32995546
Synthetic biology utilizes the Design-Build-Test-Learn pipeline for the engineering of biological systems. Typically, this requires the construction of specifically designed, large and complex DNA assemblies. The availability of cheap DNA...
7.
Robinson C, Carbonell P, Jervis A, Yan C, Hollywood K, Dunstan M, et al.
Metab Eng
. 2020 Apr;
60:168-182.
PMID: 32335188
Bio-based production of industrial chemicals using synthetic biology can provide alternative green routes from renewable resources, allowing for cleaner production processes. To efficiently produce chemicals on-demand through microbial strain engineering,...
8.
Leferink N, Dunstan M, Hollywood K, Swainston N, Currin A, Jervis A, et al.
Sci Rep
. 2019 Aug;
9(1):11936.
PMID: 31417136
Monoterpenoids are a structurally diverse group of natural products with applications as pharmaceuticals, flavourings, fragrances, pesticides, and biofuels. Recent advances in synthetic biology offer new routes to this chemical diversity...
9.
Jervis A, Carbonell P, Taylor S, Sung R, Dunstan M, Robinson C, et al.
ACS Synth Biol
. 2019 Mar;
8(7):1478-1483.
PMID: 30870592
The rapid prototyping and optimization of plasmid-based recombinant gene expression is one of the key steps in the development of bioengineered bacterial systems. Often, multiple genes or gene modules need...
10.
Jervis A, Carbonell P, Vinaixa M, Dunstan M, Hollywood K, Robinson C, et al.
ACS Synth Biol
. 2018 Dec;
8(1):127-136.
PMID: 30563328
The field of synthetic biology aims to make the design of biological systems predictable, shrinking the huge design space to practical numbers for testing. When designing microbial cell factories, most...