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Adrian Hugenmatter

Explore the profile of Adrian Hugenmatter including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Sade H, Baumgartner C, Hugenmatter A, Moessner E, Freskgard P, Niewoehner J
PLoS One . 2014 May; 9(4):e96340. PMID: 24788759
We have adapted an in vitro model of the human blood-brain barrier, the immortalized human cerebral microvascular endothelial cells (hCMEC/D3), to quantitatively measure protein transcytosis. After validating the receptor-mediated transport...
2.
Bar-Rogovsky H, Hugenmatter A, Tawfik D
J Biol Chem . 2013 Jun; 288(33):23914-27. PMID: 23788644
Serum paraoxonases (PONs) are detoxifying lactonases that were first identified in mammals. Three mammalian families are known, PON1, 2, and 3 that reside primarily in the liver. They catalyze essentially...
3.
Khersonsky O, Rosenblat M, Toker L, Yacobson S, Hugenmatter A, Silman I, et al.
Biochemistry . 2009 Jun; 48(28):6644-54. PMID: 19492856
Serum paraoxonases (PONs) are calcium-dependent lactonases with anti-atherogenic and detoxification functions. Here we describe the directed evolution and characterization of recombinant variants of serum paraoxonase PON3 that express in an...