Addison J Lana
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Explore the profile of Addison J Lana including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
174
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Recent Articles
1.
Balak C, Schlachetzki J, Lana A, West E, Hong C, DuGal J, et al.
bioRxiv
. 2024 Nov;
PMID: 39605454
Lysosomal dysfunction is causally linked to neurodegeneration in many lysosomal storage disorders (LSDs) and is associated with various age-related neurodegenerative diseases , but there is limited understanding of the mechanisms...
2.
Schlachetzki J, Gianella S, Ouyang Z, Lana A, Yang X, OBrien S, et al.
Life Sci Alliance
. 2024 Oct;
8(1).
PMID: 39467638
"Despite ART, we detected occasional microglia containing cell-associated HIV RNA and HIV DNA integrated into open regions of the host's genome (∼0.005%)" should be corrected to: "Despite ART, we detected...
3.
Schlachetzki J, Gianella S, Ouyang Z, Lana A, Yang X, OBrien S, et al.
Life Sci Alliance
. 2024 Jul;
7(10).
PMID: 39060113
The presence of HIV in sequestered reservoirs is a central impediment to a functional cure, allowing HIV to persist despite life-long antiretroviral therapy (ART), and driving a variety of comorbid...
4.
Schafer S, AlFatah Mansour A, Schlachetzki J, Pena M, Ghassemzadeh S, Mitchell L, et al.
Cell
. 2023 May;
186(10):2111-2126.e20.
PMID: 37172564
Microglia are specialized brain-resident macrophages that play crucial roles in brain development, homeostasis, and disease. However, until now, the ability to model interactions between the human brain environment and microglia...
5.
Breuss M, Yang X, Schlachetzki J, Antaki D, Lana A, Xu X, et al.
Nature
. 2022 Apr;
604(7907):689-696.
PMID: 35444276
The structure of the human neocortex underlies species-specific traits and reflects intricate developmental programs. Here we sought to reconstruct processes that occur during early development by sampling adult human tissues....
6.
Cobo I, Cheng A, Murillo-Saich J, Coras R, Torres A, Abe Y, et al.
Cell Rep
. 2022 Mar;
38(10):110489.
PMID: 35263587
Monosodium urate crystals (MSUc) induce inflammation in vivo without prior priming, raising the possibility of an initial cell-autonomous phase. Here, using genome-wide transcriptomic analysis and biochemical assays, we demonstrate that...
7.
Reid D, Reed P, Schlachetzki J, Nitulescu I, Chou G, Tsui E, et al.
Science
. 2021 Apr;
372(6537):91-94.
PMID: 33795458
Neurons are the longest-lived cells in our bodies and lack DNA replication, which makes them reliant on a limited repertoire of DNA repair mechanisms to maintain genome fidelity. These repair...
8.
SuB P, Lana A, Schlachetzki J
Neural Regen Res
. 2021 Jan;
16(9):1711-1714.
PMID: 33510059
The contribution of chronic peripheral inflammation to the pathogenesis of neurodegenerative diseases is an outstanding question. Sustained activation of the peripheral innate and adaptive immune systems occurs in the context...