Adam Zemla
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Explore the profile of Adam Zemla including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Stuart R, Mayali X, Boaro A, Zemla A, Everroad R, Nilson D, et al.
mBio
. 2016 Jun;
7(3).
PMID: 27353754
Unlabelled: Although it is becoming clear that many microbial primary producers can also play a role as organic consumers, we know very little about the metabolic regulation of photoautotroph organic...
12.
Al Olaby R, Cocquerel L, Zemla A, Saas L, Dubuisson J, Vielmetter J, et al.
PLoS One
. 2014 Oct;
9(10):e111333.
PMID: 25357246
Hepatitis C Virus (HCV) infects 200 million individuals worldwide. Although several FDA approved drugs targeting the HCV serine protease and polymerase have shown promising results, there is a need for...
13.
Zemla A, Kostova T, Gorchakov R, Volkova E, Beasley D, Cardosa J, et al.
Bioinform Biol Insights
. 2014 Jan;
8:1-16.
PMID: 24453480
A computational approach for identification and assessment of genomic sequence variability (GeneSV) is described. For a given nucleotide sequence, GeneSV collects information about the permissible nucleotide variability (changes that potentially...
14.
Rajanna C, Ouellette G, Rashid M, Zemla A, Karavis M, Zhou C, et al.
FEMS Microbiol Lett
. 2013 Mar;
343(2):113-20.
PMID: 23521061
We describe here a strain of Yersinia pestis, G1670A, which exhibits a baseline mutation rate elevated 250-fold over wild-type Y. pestis. The responsible mutation, a C to T substitution in...
15.
Borucki M, Allen J, Chen-Harris H, Zemla A, Vanier G, Mabery S, et al.
PLoS One
. 2013 Jan;
8(1):e52752.
PMID: 23308119
The high mutation rate of RNA viruses enables a diverse genetic population of viral genotypes to exist within a single infected host. In-host genetic diversity could better position the virus...
16.
Yelton A, Thomas B, Simmons S, Wilmes P, Zemla A, Thelen M, et al.
PLoS Comput Biol
. 2011 Oct;
7(10):e1002230.
PMID: 22028637
During microbial evolution, genome rearrangement increases with increasing sequence divergence. If the relationship between synteny and sequence divergence can be modeled, gene clusters in genomes of distantly related organisms exhibiting...
17.
Zemla A, Segelke B
Mutat Res
. 2010 Dec;
722(2):165-70.
PMID: 21182983
Here we present a perspective on a range of practical uses of structural genomics for mutagen research. Structural genomics is an overloaded term and requires some definition to bound the...
18.
Wu D, Hugenholtz P, Mavromatis K, Pukall R, Dalin E, Ivanova N, et al.
Nature
. 2009 Dec;
462(7276):1056-60.
PMID: 20033048
Sequencing of bacterial and archaeal genomes has revolutionized our understanding of the many roles played by microorganisms. There are now nearly 1,000 completed bacterial and archaeal genomes available, most of...
19.
Anisimov A, Dentovskaya S, Panfertsev E, Svetoch T, Kopylov P, Segelke B, et al.
Infect Genet Evol
. 2009 Oct;
10(1):137-45.
PMID: 19835996
The LcrV protein is a multifunctional virulence factor and protective antigen of the plague bacterium and is generally conserved between the epidemic strains of Yersinia pestis. We investigated the diversity...
20.
Keedy D, Williams C, Headd J, Arendall 3rd W, Chen V, Kapral G, et al.
Proteins
. 2009 Sep;
77 Suppl 9:29-49.
PMID: 19731372
For template-based modeling in the CASP8 Critical Assessment of Techniques for Protein Structure Prediction, this work develops and applies six new full-model metrics. They are designed to complement and add...