Adam R Root
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Explore the profile of Adam R Root including associated specialties, affiliations and a list of published articles.
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10
Citations
192
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Recent Articles
1.
Ingraham J, Baranov M, Costello Z, Barber K, Wang W, Ismail A, et al.
Nature
. 2023 Nov;
623(7989):1070-1078.
PMID: 37968394
Three billion years of evolution has produced a tremendous diversity of protein molecules, but the full potential of proteins is likely to be much greater. Accessing this potential has been...
2.
Molecular insights into recognition of GUCY2C by T-cell engaging bispecific antibody anti-GUCY2CxCD3
Rampuria P, Mosyak L, Root A, Svenson K, Agostino M, Lavallie E
Sci Rep
. 2023 Aug;
13(1):13408.
PMID: 37591971
The intestinal epithelial receptor Guanylyl Cyclase C (GUCY2C) is a tumor-associated cell surface antigen expressed across gastrointestinal malignancies that can serve as an efficacious target for colorectal cancer immunotherapy. Here,...
3.
Root A, Guntas G, Katragadda M, Apgar J, Narula J, Chang C, et al.
MAbs
. 2021 Jan;
13(1):1850395.
PMID: 33459147
We report here the discovery and optimization of a novel T cell retargeting anti-GUCY2C x anti-CD3ε bispecific antibody for the treatment of solid tumors. Using a combination of hybridoma, phage...
4.
Mathur D, Root A, Bugaj-Gaweda B, Bisulco S, Tan X, Fang W, et al.
Clin Cancer Res
. 2020 Jan;
26(9):2188-2202.
PMID: 31996389
Purpose: Gastrointestinal cancers remain areas of high unmet need despite advances in targeted and immunotherapies. Here, we demonstrate potent, tumor-selective efficacy with PF-07062119, a T-cell engaging CD3 bispecific targeting tumors...
5.
Root A, Cao W, Li B, LaPan P, Meade C, Sanford J, et al.
Antibodies (Basel)
. 2019 Sep;
5(1).
PMID: 31557987
Bispecific antibodies offer a promising approach for the treatment of cancer but can be challenging to engineer and manufacture. Here we report the development of PF-06671008, an extended-half-life dual-affinity re-targeting...
6.
Fisher T, Hooper A, Lucas J, Clark T, Rohner A, Peano B, et al.
Cancer Immunol Immunother
. 2017 Oct;
67(2):247-259.
PMID: 29067496
Strong evidence exists supporting the important role T cells play in the immune response against tumors. Still, the ability to initiate tumor-specific immune responses remains a challenge. Recent clinical trials...
7.
Silver M, Nucci N, Root A, Reed K, Sower S
Endocrinology
. 2005 May;
146(8):3351-61.
PMID: 15878963
A full-length transcript encoding a functional type II GnRH receptor was cloned from the pituitary of the sea lamprey, Petromyzon marinus. The current study is the first to identify a...
8.
Kavanaugh S, Root A, Sower S
Gen Comp Endocrinol
. 2005 Feb;
141(1):76-83.
PMID: 15707605
Gonadotropin releasing hormone (GnRH) is the key hypothalamic neurohormone that is critical in its role of reproduction in all vertebrates. There are currently twenty-four known forms of GnRH that have...
9.
Root A, Nucci N, Sanford J, Rubin B, Trudeau V, Sower S
Brain Behav Evol
. 2004 Oct;
65(1):60-70.
PMID: 15475659
The distribution of lamprey gonadotropin-releasing hormone (GnRH)-I and -III has been extensively characterized by immunocytochemistry in the forebrain of the sea lamprey, Petromyzon marinus. However, the cellular location of lamprey...
10.
Root A, Sanford J, Kavanaugh S, Sower S
Comp Biochem Physiol A Mol Integr Physiol
. 2004 Sep;
138(4):493-501.
PMID: 15369839
gamma-Aminobutyric acid (GABA) is a neurotransmitter with a demonstrated neuroregulatory role in reproduction in most representative species of vertebrate classes via the hypothalamus. The role of GABA on the hypothalamus-pituitary...