Adam R Johnson
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Explore the profile of Adam R Johnson including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Sahni J, McCue I, Johnson A, Schake M, Sotelo L, Turner J, et al.
Ultrasound Med Biol
. 2024 Sep;
50(12):1893-1902.
PMID: 39306482
Objective: To determine the sensitivity of vascular endothelial cells to long durations of low-intensity pulsed ultrasound (LIPUS) compared to normal flow and identify the duration that maximizes expression of two...
2.
Terrett J, Ly J, Katavolos P, Hasselgren C, Laing S, Zhong F, et al.
J Med Chem
. 2024 Mar;
67(5):3287-3306.
PMID: 38431835
Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium ion channel highly expressed in the primary sensory neurons, functioning as a polymodal sensor for exogenous and endogenous stimuli, and...
3.
Wile B, Griffith C, Johnson A
Acta Crystallogr E Crystallogr Commun
. 2023 Sep;
79(Pt 9):782-785.
PMID: 37693661
The title compound, systematic name 4,4',6,6'-tetrachloro-2,2'-{[(2-methoxy-ethyl)azanediyl]bis(methylene)}diphenol (CHClNO, ), was prepared a modified Mannich reaction between 2-meth-oxy-ethyl-amine, 2,4-di-chloro-phenol, and aqueous formaldehyde. The resulting amine bis-(phenol) provides an inter-esting comparison to related...
4.
Crawford J, Feng J, Brightbill H, Johnson A, Wright M, Kolesnikov A, et al.
Bioorg Med Chem Lett
. 2023 Apr;
89:129277.
PMID: 37105490
Inhibition of NF-κB inducing kinase (NIK) has been pursued as a promising therapeutic target for autoimmune disorders due to its highly regulated role in key steps of the NF-κB signaling...
5.
Hickstein D, Reinheimer E, Johnson A, OLeary D
IUCrdata
. 2022 Nov;
6(Pt 10):x211043.
PMID: 36340982
While endeavoring to synthesize new chlorinated ligands for ruthenium-based metathesis catalysts, the title compound dimethyl 4,5-di-chloro-phthalate, CHClO, was prepared from commercially available 4,5-di-chloro-phthalic acid in ∼77% yield. The title mol-ecule,...
6.
Show V, Fok E, Johnson A
IUCrdata
. 2022 Nov;
5(Pt 12):x201576.
PMID: 36337339
The title compound, CHNO, crystallizes in the ortho-rhom-bic space group 222 with one mol-ecule in the asymmetric unit. An intra-molecular hydrogen bond orients the phenol hydroxyl group toward the imine...
7.
Sha F, Johnson A
IUCrdata
. 2022 Nov;
5(Pt 12):x201580.
PMID: 36337338
The title compound, CHFNO, crystallizes in the ortho-rhom-bic space group 222. A hydrogen-bonding network between the tertiary alcohol group and the fluoro substituent results in [010] chains in the solid...
8.
Conrad-Marut L, Reinheimer E, Johnson A
Acta Crystallogr E Crystallogr Commun
. 2021 Oct;
77(Pt 10):1010-1013.
PMID: 34667628
The synthesis and crystal structure of the title racemic compound, [Co(CHN)]Cl.{[Na(HO)]Cl}, are reported. The trivalent cobalt atom, which resides on a crystallographic threefold axis, is chelated by a single ethyl-ene...
9.
Sha F, Shimizu E, Slocumb H, Towell S, Zhen Y, Porter H, et al.
Dalton Trans
. 2020 Aug;
49(35):12418-12431.
PMID: 32852029
Catalysis using earth abundant metals is an important goal due to the relative scarcity and expense of precious metal catalysts. It would be even more beneficial to use earth abundant...
10.
Crawford J, Lee W, Johnson A, Delatorre K, Chen J, Eigenbrot C, et al.
ACS Med Chem Lett
. 2020 Aug;
11(8):1588-1597.
PMID: 32832028
Bruton's tyrosine kinase (Btk) is thought to play a pathogenic role in chronic immune diseases such as rheumatoid arthritis and lupus. While covalent, irreversible Btk inhibitors are approved for treatment...