Adam M Packer
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Explore the profile of Adam M Packer including associated specialties, affiliations and a list of published articles.
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29
Citations
1789
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Recent Articles
1.
Gauld O, Packer A, Russell L, Dalgleish H, Iuga M, Sacadura F, et al.
Neuron
. 2024 May;
112(14):2386-2403.e6.
PMID: 38729150
To investigate which activity patterns in sensory cortex are relevant for perceptual decision-making, we combined two-photon calcium imaging and targeted two-photon optogenetics to interrogate barrel cortex activity during perceptual discrimination....
2.
Shah P, Valiante T, Packer A
Cell Rep
. 2024 May;
43(5):114189.
PMID: 38703365
The propagation of a seizure wavefront in the cortex divides an intensely firing seizure core from a low-firing seizure penumbra. Seizure propagation is currently thought to generate strong activation of...
3.
Russell L, Fisek M, Yang Z, Tan L, Packer A, Dalgleish H, et al.
Nat Commun
. 2024 Mar;
15(1):2456.
PMID: 38503769
The mechanistic link between neural circuit activity and behavior remains unclear. While manipulating cortical activity can bias certain behaviors and elicit artificial percepts, some tasks can still be solved when...
4.
Lees R, Bianco I, Campbell R, Orlova N, Peterka D, Pichler B, et al.
bioRxiv
. 2024 Feb;
PMID: 38328224
The goal of this protocol is to enable better characterisation of multiphoton microscopy hardware across a large user base. The scope of this protocol is purposefully limited to focus on...
5.
Lees R, Pichler B, Packer A
Neurophotonics
. 2024 Feb;
11(1):015006.
PMID: 38322022
Significance: Two-photon optogenetics combines nonlinear excitation with noninvasive activation of neurons to enable the manipulation of neural circuits with a high degree of spatial precision. Combined with two-photon population calcium...
6.
Ocana-Santero G, Packer A, Sharp T, Butt S
ACS Chem Neurosci
. 2024 Jan;
15(3):456-461.
PMID: 38251903
The recent development of genetically encoded fluorescent neurotransmitter biosensors has opened the door to recording serotonin (5-hydroxytryptamine, 5-HT) signaling dynamics with high temporal and spatial resolution . While this represents...
7.
Hu Q, Hailstone M, Wang J, Wincott M, Stoychev D, Atilgan H, et al.
Light Sci Appl
. 2023 Nov;
12(1):270.
PMID: 37953294
The resolution and contrast of microscope imaging is often affected by aberrations introduced by imperfect optical systems and inhomogeneous refractive structures in specimens. Adaptive optics (AO) compensates these aberrations and...
8.
Grimstvedt J, Shelton A, Hoerder-Suabedissen A, Oliver D, Berndtsson C, Blankvoort S, et al.
J Comp Neurol
. 2023 Oct;
531(17):1772-1795.
PMID: 37782702
Accurate anatomical characterizations are necessary to investigate neural circuitry on a fine scale, but for the rodent claustrum complex (CLCX), this has yet to be fully accomplished. The CLCX is...
9.
Rowland J, van der Plas T, Loidolt M, Lees R, Keeling J, Dehning J, et al.
Nat Neurosci
. 2023 Aug;
26(9):1584-1594.
PMID: 37640911
Brains are composed of anatomically and functionally distinct regions performing specialized tasks, but regions do not operate in isolation. Orchestration of complex behaviors requires communication between brain regions, but how...
10.
Hoerder-Suabedissen A, Ocana-Santero G, Draper T, Scott S, Kimani J, Shelton A, et al.
Cereb Cortex
. 2022 Sep;
33(7):3944-3959.
PMID: 36104852
The claustrum is known for its extensive connectivity with many other forebrain regions, but its elongated shape and deep location have made further study difficult. We have sought to understand...