Adam Lehar
Overview
Explore the profile of Adam Lehar including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
137
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0
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Recent Articles
1.
Lee S, Lehar A, Rydzik R, Youngstrom D, Bhasin S, Liu Y, et al.
Skelet Muscle
. 2022 Mar;
12(1):7.
PMID: 35287700
Background: Myostatin (MSTN) is a transforming growth factor-ß superfamily member that acts as a major regulator of skeletal muscle mass. GDF-11, which is highly related to MSTN, plays multiple roles...
2.
Liu Y, Lehar A, Rydzik R, Chandok H, Lee Y, Youngstrom D, et al.
Proc Natl Acad Sci U S A
. 2021 Aug;
118(33).
PMID: 34385332
Skeletal muscle and bone homeostasis are regulated by members of the myostatin/GDF-11/activin branch of the transforming growth factor-β superfamily, which share many regulatory components, including inhibitory extracellular binding proteins and...
3.
Lee S, Lehar A, Liu Y, Ly C, Pham Q, Michaud M, et al.
Proc Natl Acad Sci U S A
. 2020 Nov;
117(49):30907-30917.
PMID: 33219121
Myostatin (MSTN) is a transforming growth factor-β (TGF-β) family member that normally acts to limit muscle growth. The function of MSTN is partially redundant with that of another TGF-β family...
4.
Lee S, Lehar A, Meir J, Koch C, Morgan A, Warren L, et al.
Proc Natl Acad Sci U S A
. 2020 Sep;
117(38):23942-23951.
PMID: 32900939
Among the physiological consequences of extended spaceflight are loss of skeletal muscle and bone mass. One signaling pathway that plays an important role in maintaining muscle and bone homeostasis is...
5.
Bondulich M, Jolinon N, Osborne G, Smith E, Rattray I, Neueder A, et al.
Sci Rep
. 2017 Oct;
7(1):14275.
PMID: 29079832
Huntington's disease (HD) is an inherited neurodegenerative disorder of which skeletal muscle atrophy is a common feature, and multiple lines of evidence support a muscle-based pathophysiology in HD mouse models....
6.
Lee Y, Lehar A, Sebald S, Liu M, Swaggart K, Talbot Jr C, et al.
Hum Mol Genet
. 2015 Jul;
24(20):5711-9.
PMID: 26206886
Myostatin is a secreted signaling molecule that normally acts to limit muscle growth. As a result, there is extensive effort directed at developing drugs capable of targeting myostatin to treat...