Adam K Walker
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Explore the profile of Adam K Walker including associated specialties, affiliations and a list of published articles.
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95
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2249
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Recent Articles
11.
Mathew N, McCaffrey D, Walker A, Mallitt K, Masi A, Morris M, et al.
Mol Autism
. 2024 Jan;
15(1):4.
PMID: 38233886
Background: Gastrointestinal symptoms and inflammatory gastrointestinal diseases exist at higher rates in the autistic population. It is not clear however whether autism is associated with elevated gastrointestinal inflammation as studies...
12.
Jacobs M, San Gil R, Walker A
Trends Neurosci
. 2023 Nov;
47(2):87-89.
PMID: 38030509
In a recent study, Guo and colleagues characterised the function of an elusive endoplasmic reticulum (ER) anion channel protein, Chloride Channel CLiC Like 1 (CLCC1), and identified rare CLCC1 variants...
13.
Dubowitz J, Ziegler A, Beare R, Jost-Brinkmann F, Walker A, Gillis R, et al.
PLoS One
. 2023 Nov;
18(11):e0293905.
PMID: 38011080
Background: Surgery is essential for curative treatment of solid tumors. Evidence from recent retrospective clinical analyses suggests that use of propofol-based total intravenous anesthesia during cancer resection surgery is associated...
14.
Lawther A, Zieba J, Fang Z, Furlong T, Conn I, Govindaraju H, et al.
Genes (Basel)
. 2023 Sep;
14(9).
PMID: 37761857
Mitochondrial dysfunction is strongly associated with autism spectrum disorder (ASD) and the gene is linked to autism inheritance. However, the biological basis of this linkage is unknown notwithstanding independent reports...
15.
Leung B, Merlin S, Walker A, Lawther A, Paxinos G, Eapen V, et al.
Behav Brain Res
. 2023 Aug;
452:114610.
PMID: 37541448
Cortico-striatal neurocircuits mediate goal-directed and habitual actions which are necessary for adaptive behaviour. It has recently been proposed that some of the core symptoms of autism spectrum disorder (ASD) and...
16.
Swanson M, Mrkela M, Murray H, Cao M, Turner C, Curtis M, et al.
Acta Neuropathol Commun
. 2023 Apr;
11(1):69.
PMID: 37118836
Microglia, the innate immune cells of the brain, are activated by damage or disease. In mouse models of amyotrophic lateral sclerosis (ALS), microglia shift from neurotrophic to neurotoxic states with...
17.
Chang A, Botteri E, Gillis R, Lofling L, Le C, Ziegler A, et al.
Sci Transl Med
. 2023 Apr;
15(693):eadf1147.
PMID: 37099632
Beta-adrenergic blockade has been associated with improved cancer survival in patients with triple-negative breast cancer (TNBC), but the mechanisms of these effects remain unclear. In clinical epidemiological analyses, we identified...
18.
Luan W, Wright A, Brown-Wright H, Le S, San Gil R, Madrid San Martin L, et al.
Mol Psychiatry
. 2023 Apr;
28(6):2445-2461.
PMID: 37012334
TAR DNA binding protein 43 (TDP-43) pathology is a key feature of over 95% of amyotrophic lateral sclerosis (ALS) and nearly half of frontotemporal dementia (FTD) cases. The pathogenic mechanisms...
19.
Zhu Y, Webster M, Walker A, Massa P, Middleton F, Weickert C
Brain Behav Immun
. 2023 Mar;
111:46-60.
PMID: 36972743
Transcript levels of cytokines and SERPINA3 have been used to define a substantial subset (40%) of individuals with schizophrenia with elevated inflammation and worse neuropathology in the dorsolateral prefrontal cortex...
20.
Sager R, Walker A, Middleton F, Robinson K, Webster M, Gentile K, et al.
Brain Behav Immun
. 2023 Mar;
111:186-201.
PMID: 36958512
In addition to their traditional roles in immune cell communication, cytokines regulate brain development. Cytokines are known to influence neural cell generation, differentiation, maturation, and survival. However, most work on...