Adam J Trewin
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Explore the profile of Adam J Trewin including associated specialties, affiliations and a list of published articles.
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26
Citations
564
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Recent Articles
1.
Silver J, Trewin A, Loke S, Croft L, Ziemann M, Soria M, et al.
FASEB J
. 2024 Dec;
38(23):e70223.
PMID: 39625361
Mitochondria are central to cellular function, particularly in metabolically active tissues such as skeletal muscle. Nuclear-encoded RNAs typically localize within the nucleus and cytosol but a small population may also...
2.
Knowles O, Soria M, Saner N, Trewin A, Alexander S, Roberts S, et al.
Physiol Genomics
. 2024 May;
56(7):506-518.
PMID: 38766755
Both sleep loss and exercise regulate gene expression in skeletal muscle, yet little is known about how the interaction of these stressors affects the transcriptome. The aim of this study...
3.
Weeks K, Kiriazis H, Wadley G, Masterman E, Sergienko N, Raaijmakers A, et al.
J Mol Med (Berl)
. 2023 Nov;
102(1):95-111.
PMID: 37987775
Diabetic cardiomyopathy describes heart disease in patients with diabetes who have no other cardiac conditions but have a higher risk of developing heart failure. Specific therapies to treat the diabetic...
4.
Trewin A, Weeks K, Wadley G, Lamon S
Am J Physiol Cell Physiol
. 2023 Sep;
325(4):C1097-C1105.
PMID: 37721002
Cardiomyocyte calcium homeostasis is a tightly regulated process. The mitochondrial calcium uniporter (MCU) complex can buffer elevated cytosolic Ca levels and consists of pore-forming proteins including MCU, and various regulatory...
5.
Trewin A, Silver J, Dillon H, Della Gatta P, Parker L, Hiam D, et al.
BMC Biol
. 2022 Jul;
20(1):164.
PMID: 35850762
Background: Mitochondria have an essential role in regulating metabolism and integrate environmental and physiological signals to affect processes such as cellular bioenergetics and response to stress. In the metabolically active...
6.
Malamouli M, Levinger I, McAinch A, Trewin A, Rodgers R, Moreno-Asso A
J Mol Endocrinol
. 2022 Jan;
68(3):R11-R23.
PMID: 35060480
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting pre-menopausal women and involves metabolic dysregulation. Despite the high prevalence of insulin resistance, the existence of mitochondrial dysregulation and its...
7.
Lindsay A, Trewin A, Sadler K, Laird C, Della Gatta P, Russell A
FASEB J
. 2021 Nov;
35(12):e22034.
PMID: 34780665
Mutation to the gene encoding dystrophin can cause Duchenne muscular dystrophy (DMD) and increase the sensitivity to stress in vertebrate species, including the mdx mouse model of DMD. Behavioral stressors...
8.
McKeegan K, Mason S, Trewin A, Keske M, Wadley G, Della Gatta P, et al.
Redox Biol
. 2021 May;
44:102005.
PMID: 34049222
Reactive oxygen species (ROS) are well known for their role in insulin resistance and the development of cardiometabolic disease including type 2 diabetes mellitus (T2D). Conversely, evidence supports the notion...
9.
Mason S, Trewin A, Parker L, Wadley G
Redox Biol
. 2020 Mar;
35:101471.
PMID: 32127289
Antioxidant supplements are commonly consumed by endurance athletes to minimize exercise-induced oxidative stress, with the intention of enhancing recovery and improving performance. There are numerous commercially available nutritional supplements that...
10.
Berry B, Trewin A, Milliken A, Baldzizhar A, Amitrano A, Lim Y, et al.
EMBO Rep
. 2020 Feb;
21(4):e49113.
PMID: 32043300
Mitochondrial respiration generates an electrochemical proton gradient across the mitochondrial inner membrane called protonmotive force (PMF) to drive diverse functions and synthesize ATP. Current techniques to manipulate the PMF are...