Adam H Tencer
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Explore the profile of Adam H Tencer including associated specialties, affiliations and a list of published articles.
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13
Citations
232
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Recent Articles
1.
Vann K, Sharma R, Hsu C, Devoucoux M, Tencer A, Zeng L, et al.
Nat Commun
. 2025 Mar;
16(1):2235.
PMID: 40044670
The histone H3K36-specific methyltransferase ASH1L plays a critical role in development and is frequently dysregulated in human diseases, particularly cancer. Here, we report on the biological functions of the C-terminal...
2.
Tencer A, Yu Y, Causse S, Campbell G, Klein B, Xuan H, et al.
Nat Struct Mol Biol
. 2023 Jul;
30(9):1265-1274.
PMID: 37524969
The inhibitor of apoptosis protein BIRC2 regulates fundamental cell death and survival signaling pathways. Here we show that BIRC2 accumulates in the nucleus via binding of its second and third...
3.
Liu J, Chaves-Arquero B, Wei P, Tencer A, Ruiz-Albor A, Zhang G, et al.
Structure
. 2023 Mar;
31(5):511-517.e3.
PMID: 36990095
F-box DNA helicase 1 (FBH1) is involved in the regulation of cell responses to replicative stress. FBH1 is recruited to stalled DNA replication fork by PCNA where it inhibits homologous...
4.
Tencer A, Liu J, Zhu J, Burkholder N, Zhang Y, Wu W, et al.
Sci Rep
. 2022 Apr;
12(1):6063.
PMID: 35411094
The E3 ubiquitin ligase HERC2 has been linked to neurological diseases and cancer, however it remains a poorly characterized human protein. Here, we show that the ZZ domain of HERC2...
5.
Tencer A, Cox K, Wright G, Zhang Y, Petell C, Klein B, et al.
Nat Commun
. 2020 Oct;
11(1):5466.
PMID: 33122719
Human Microrchidia 4 (MORC4) is associated with acute and chronic pancreatitis, inflammatory disorders and cancer but it remains largely uncharacterized. Here, we describe the structure-function relationship of MORC4 and define...
6.
Vann K, Tencer A, Kutateladze T
Signal Transduct Target Ther
. 2020 Oct;
5(1):234.
PMID: 33037187
No abstract available.
7.
Zhang Y, Bertulat B, Tencer A, Ren X, Wright G, Black J, et al.
iScience
. 2019 Jul;
17:182-189.
PMID: 31284181
Phase separation can produce local structures with specific functionality in the cell, and in the nucleus, this can lead to chromatin reorganization. Microrchidia 3 (MORC3) is a human ATPase that...
8.
Zhang Y, Klein B, Cox K, Bertulat B, Tencer A, Holden M, et al.
Proc Natl Acad Sci U S A
. 2019 Mar;
116(13):6111-6119.
PMID: 30850548
Microrchidia 3 (MORC3) is a human protein linked to autoimmune disorders, Down syndrome, and cancer. It is a member of a newly identified family of human ATPases with an uncharacterized...
9.
Mi W, Zhang Y, Lyu J, Wang X, Tong Q, Peng D, et al.
Nat Commun
. 2018 Sep;
9(1):3759.
PMID: 30217978
Recognition of histones by epigenetic readers is a fundamental mechanism for the regulation of chromatin and transcription. Most reader modules target specific post-translational modifications on histones. Here, we report the...
10.
Gatchalian J, Wang X, Ikebe J, Cox K, Tencer A, Zhang Y, et al.
Nat Commun
. 2017 Nov;
8(1):1489.
PMID: 29138400
Combinatorial polyvalent contacts of histone-binding domains or readers commonly mediate localization and activities of chromatin-associated proteins. A pair of readers, the PHD fingers of the protein CHD4, has been shown...