Ada Shao
Overview
Explore the profile of Ada Shao including associated specialties, affiliations and a list of published articles.
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12
Citations
409
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Recent Articles
1.
Shum E, Jones S, Shao A, Chousal J, Krause M, Chan W, et al.
Cell
. 2016 Apr;
165(2):382-95.
PMID: 27040500
Gene duplication is a major evolutionary force driving adaptation and speciation, as it allows for the acquisition of new functions and can augment or diversify existing functions. Here, we report...
2.
Shao A, Wilkinson M
EMBO Mol Med
. 2014 Nov;
6(12):1518-20.
PMID: 25378479
In this issue of EMBO Molecular Medicine, Bhuvanagiri et al report on a chemical means to convert molecular junk into gold. They identify a chemical inhibitor of a quality control...
3.
De Vicente J, Lemoine R, Bartlett M, Hermann J, Hekmat-Nejad M, Henningsen R, et al.
Bioorg Med Chem Lett
. 2014 Sep;
24(21):4969-75.
PMID: 25262541
The discovery of a novel series of pyrrolopyrazines as JAK inhibitors with comparable enzyme and cellular activity to tofacitinib is described. The series was identified using a scaffold hopping approach...
4.
Lou C, Shao A, Shum E, Espinoza J, Huang L, Karam R, et al.
Cell Rep
. 2014 Feb;
6(4):748-64.
PMID: 24529710
The mechanisms dictating whether a cell proliferates or differentiates have undergone intense scrutiny, but they remain poorly understood. Here, we report that UPF1, a central component in the nonsense-mediated RNA...
5.
Gong L, Han X, Silva T, Tan Y, Goyal B, Tivitmahaisoon P, et al.
Bioorg Med Chem Lett
. 2013 May;
23(12):3565-9.
PMID: 23664880
A novel series of indole/indazole-aminopyrimidines was designed and synthesized with an aim to achieve optimal potency and selectivity for the c-Jun kinase family or JNKs. Structure guided design was used...
6.
Jaime-Figueroa S, De Vicente J, Hermann J, Jahangir A, Jin S, Kuglstatter A, et al.
Bioorg Med Chem Lett
. 2013 Apr;
23(9):2522-6.
PMID: 23541670
We report the discovery of a novel series of ATP-competitive Janus kinase 3 (JAK3) inhibitors based on the 5H-pyrrolo[2,3-b]pyrazine scaffold. The initial leads in this series, compounds 1a and 1h,...
7.
Palmer W, Alam M, Arzeno H, Chang K, Dunn J, Goldstein D, et al.
Bioorg Med Chem Lett
. 2013 Jan;
23(5):1486-92.
PMID: 23352510
A series of amino-pyrimidines was developed based upon an initial kinase cross-screening hit from a CDK2 program. Kinase profiling and structure-based drug design guided the optimization from the initial 1,2,3-benzotriazole...
8.
Soth M, Hermann J, Yee C, Alam M, Barnett J, Berry P, et al.
J Med Chem
. 2012 Dec;
56(1):345-56.
PMID: 23214979
The Janus kinases (JAKs) are involved in multiple signaling networks relevant to inflammatory diseases, and inhibition of one or more members of this class may modulate disease activity or progression....
9.
Gong L, Tan Y, Boice G, Abbot S, McCaleb K, Iyer P, et al.
Bioorg Med Chem Lett
. 2012 Nov;
22(24):7381-7.
PMID: 23142618
A novel series of highly selective JNK inhibitors based on the 4-quinolone scaffold was designed and synthesized. Structure based drug design was utilized to guide the compound design as well...
10.
Villasenor A, Wong A, Shao A, Garg A, Donohue T, Kuglstatter A, et al.
Acta Crystallogr D Biol Crystallogr
. 2012 Aug;
68(Pt 8):893-900.
PMID: 22868754
Focused acoustic energy allows accurate and precise liquid transfer on scales from picolitre to microlitre volumes. This technology was applied in protein crystallization, successfully transferring a diverse set of proteins...