Abraham J Langseth
Overview
Explore the profile of Abraham J Langseth including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
643
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0
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Recent Articles
1.
Pearson A, Allen C, Fangusaro J, Hutter C, Witt O, Weiner S, et al.
Eur J Cancer
. 2022 Nov;
177:120-142.
PMID: 36335782
As the mitogen-activated protein kinase (MAPK) signalling pathway is activated in many paediatric cancers, it is an important therapeutic target. Currently, a range of targeted MAPK pathway inhibitors are being...
2.
Wang J, Yang L, Jiang M, Zhao C, Liu X, Berry K, et al.
J Neurosci
. 2022 Oct;
42(45):8542-8555.
PMID: 36198499
The oligodendrocyte (OL) lineage transcription factor Olig2 is expressed throughout oligodendroglial development and is essential for oligodendroglial progenitor specification and differentiation. It was previously reported that deletion of enhanced the...
3.
Heo D, Ling J, Molina-Castro G, Langseth A, Waisman A, Nave K, et al.
Elife
. 2022 Mar;
11.
PMID: 35311646
Generation of oligodendrocytes in the adult brain enables both adaptive changes in neural circuits and regeneration of myelin sheaths destroyed by injury, disease, and normal aging. This transformation of oligodendrocyte...
4.
Hughes E, Orthmann-Murphy J, Langseth A, Bergles D
Nat Neurosci
. 2018 Mar;
21(5):696-706.
PMID: 29556025
Oligodendrocyte generation in the adult CNS provides a means to adapt the properties of circuits to changes in life experience. However, little is known about the dynamics of oligodendrocytes and...
5.
Langseth A, Kim J, Ugolino J, Shah Y, Hwang H, Wang J, et al.
Sci Rep
. 2017 Jul;
7(1):5685.
PMID: 28720882
A hexanucleotide repeat expansion in the C9orf72 gene is the most common cause of inherited forms of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Both loss-of-function and gain-of-function mechanisms have...
6.
Agarwal A, Wu P, Hughes E, Fukaya M, Tischfield M, Langseth A, et al.
Neuron
. 2017 Jan;
93(3):587-605.e7.
PMID: 28132831
Astrocytes extend highly branched processes that form functionally isolated microdomains, facilitating local homeostasis by redistributing ions, removing neurotransmitters, and releasing factors to influence blood flow and neuronal activity. Microdomains exhibit...
7.
Jin J, Peng Q, Hou Z, Jiang M, Wang X, Langseth A, et al.
Hum Mol Genet
. 2015 Jan;
24(9):2508-27.
PMID: 25609071
White matter abnormalities have been reported in premanifest Huntington's disease (HD) subjects before overt striatal neuronal loss, but whether the white matter changes represent a necessary step towards further pathology...
8.
Pozniak C, Langseth A, Dijkgraaf G, Choe Y, Werb Z, Pleasure S
Proc Natl Acad Sci U S A
. 2010 Nov;
107(50):21795-800.
PMID: 21098272
Oligodendrocyte precursor cells (OPCs) are lineage-restricted progenitors generally limited in vivo to producing oligodendrocytes. Mechanisms controlling genesis of OPCs are of interest because of their importance in myelin development and...
9.
Langseth A, Munji R, Choe Y, Huynh T, Pozniak C, Pleasure S
J Neurosci
. 2010 Oct;
30(40):13367-72.
PMID: 20926663
Oligodendrocyte precursor cells (OPCs) are generated from multiple progenitor domains in the telencephalon in developmental succession from ventral to dorsal. Previous studies showed that Wnt signaling inhibits the differentiation of...