Abraham D Lee
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Explore the profile of Abraham D Lee including associated specialties, affiliations and a list of published articles.
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10
Citations
264
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Recent Articles
1.
Muturi H, Ghadieh H, Abdolahipour R, Stankus H, Belew G, Liu J, et al.
Metabolism
. 2023 Apr;
144:155562.
PMID: 37088122
Objectives: Hepatocytic CEACAM1 plays a critical role in NASH pathogenesis, as bolstered by the development of insulin resistance, visceral obesity, steatohepatitis and fibrosis in mice with global Ceacam1 (Cc1) deletion....
2.
Helal R, Muturi H, Lee A, Li W, Ghadieh H, Najjar S
Int J Mol Sci
. 2022 Apr;
23(8).
PMID: 35457157
(1) Background: Mice with global deletion developed plaque-like aortic lesions even on C57BL/6J background in the presence of increased endothelial cell permeability and insulin resistance. Loss of endothelial gene caused...
3.
Muturi H, Khuder S, Ghadieh H, Esakov E, Noh H, Kang H, et al.
Cells
. 2021 Aug;
10(8).
PMID: 34440862
CEACAM1 regulates endothelial barrier integrity. Because insulin signaling in extrahepatic target tissues is regulated by insulin transport through the endothelium, we aimed at investigating the metabolic role of endothelial CEACAM1....
4.
Helal R, Russo L, Ghadieh H, Muturi H, Asalla S, Lee A, et al.
Metabolism
. 2021 May;
121:154801.
PMID: 34058224
Objective: NAFLD is a complex disease marked by cellular abnormalities leading to NASH. NAFLD patients manifest low hepatic levels of CEACAM1, a promoter of insulin clearance. Consistently, Cc1 null mice...
5.
Al-Share Q, DeAngelis A, Lester S, Bowman T, Ramakrishnan S, Abdallah S, et al.
Diabetes
. 2015 May;
64(8):2780-90.
PMID: 25972571
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulates insulin sensitivity by promoting hepatic insulin clearance. Liver-specific inactivation or global null-mutation of Ceacam1 impairs hepatic insulin extraction to cause chronic hyperinsulinemia,...
6.
Bowman T, Ramakrishnan S, Kaw M, Lee S, Patel P, Golla V, et al.
Endocrinology
. 2010 Sep;
151(11):5157-64.
PMID: 20861239
Rats selectively bred for low aerobic running capacity exhibit the metabolic syndrome, including hyperinsulinemia, insulin resistance, visceral obesity, and dyslipidemia. They also exhibit features of nonalcoholic steatohepatitis, including chicken-wire fibrosis,...
7.
Heinrich G, Ghosh S, DeAngelis A, Schroeder-Gloeckler J, Patel P, Castaneda T, et al.
Gastroenterology
. 2010 Apr;
139(2):644-52, 652.e1.
PMID: 20381490
Background & Aims: The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a transmembrane glycoprotein with pleotropic functions, including clearance of hepatic insulin. We investigated the functions of the related...
8.
Koch L, Green C, Lee A, Hornyak J, Cicila G, Britton S
Am J Physiol Regul Integr Comp Physiol
. 2004 Nov;
288(2):R466-72.
PMID: 15528391
An inverse relationship between initial level of physical capacity and the magnitude of response to training is termed the principle of initial value. We tested the operation of this principle...
9.
Dai T, Abou-Rjaily G, Al-Share Q, Yang Y, Fernstrom M, DeAngelis A, et al.
J Biol Chem
. 2004 Aug;
279(43):45155-61.
PMID: 15316023
Inactivation of CEACAM1 in L-SACC1 mice by a dominant-negative transgene in liver impairs insulin clearance and increases serum free fatty acid (FFA) levels, resulting in insulin resistance. The contribution of...
10.
Poy M, Yang Y, Rezaei K, Fernstrom M, Lee A, Kido Y, et al.
Nat Genet
. 2002 Feb;
30(3):270-6.
PMID: 11850617
We hypothesized that insulin stimulates phosphorylation of CEACAM1 which in turn leads to upregulation of receptor-mediated insulin endocytosis and degradation in the hepatocyte. We have generated transgenic mice over-expressing in...