Abigail Pearce
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Explore the profile of Abigail Pearce including associated specialties, affiliations and a list of published articles.
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9
Citations
74
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Recent Articles
1.
Pearce A, Redfern-Nichols T, Wills E, Rosa M, Manulak I, Sisk C, et al.
J Cell Sci
. 2025 Jan;
138(1).
PMID: 39810711
G protein-coupled receptor (GPCR) signalling pathways underlie numerous physiological processes, are implicated in many diseases and are major targets for therapeutics. There are more than 800 GPCRs, which together transduce...
2.
Weizmann T, Pearce A, Griffin P, Schild A, Flasshoff M, Grossenbacher P, et al.
Cells
. 2025 Jan;
13(24.
PMID: 39768211
The adenosine A1 receptor (AR) is a promising target for pain treatment. However, the development of therapeutic agonists is hampered by adverse effects, mainly including sedation, bradycardia, hypotension, or respiratory...
3.
GPR35 agonists inhibit TRPA1-mediated colonic nociception through suppression of substance P release
Gupta R, Higham J, Pearce A, Urriola-Munoz P, Barker K, Paine L, et al.
Pain
. 2024 Oct;
166(3):596-613.
PMID: 39382322
The development of nonopioid analgesics for the treatment of abdominal pain is a pressing clinical problem. To address this, we examined the expression of G i/o -coupled receptors, which typically...
4.
Malcharek M, Pearce A, Brighton C, Hornigold D, Ladds G
J Mol Endocrinol
. 2024 Sep;
73(4).
PMID: 39292606
Receptor activity-modifying proteins (RAMPs) modulate the expression and activity of numerous G protein-coupled receptors, primarily those within class B1. These receptors have important physiological roles, including the regulation of food...
5.
Huang X, Chorianopoulou A, Kalkounou P, Georgiou M, Pousias A, Davies A, et al.
J Med Chem
. 2024 Jul;
67(15):13117-13146.
PMID: 39073853
Antagonism of the human adenosine A receptor (hAR) has potential therapeutic application. Alchemical relative binding free energy calculations of and suggested that the combination of a 3-(2,6-dichlorophenyl)-isoxazolyl group with 2-pyridinyl...
6.
Gandasi N, Gao R, Kothegala L, Pearce A, Santos C, Acreman S, et al.
Diabetologia
. 2023 Dec;
67(3):528-546.
PMID: 38127123
Aims/hypothesis: Diabetes mellitus is associated with impaired insulin secretion, often aggravated by oversecretion of glucagon. Therapeutic interventions should ideally correct both defects. Glucagon-like peptide 1 (GLP-1) has this capability but...
7.
Pearce A, Redfern-Nichols T, Harris M, Poyner D, Wigglesworth M, Ladds G
Front Physiol
. 2022 Apr;
13:840763.
PMID: 35422711
Signalling of the calcitonin-like receptor (CLR) is multifaceted, due to its interaction with receptor activity modifying proteins (RAMPs), and three endogenous peptide agonists. Previous studies have focused on the bias...
8.
Marti-Solano M, Crilly S, Malinverni D, Munk C, Harris M, Pearce A, et al.
Nature
. 2020 Nov;
588(7838):E24.
PMID: 33244189
No abstract available.
9.
Marti-Solano M, Crilly S, Malinverni D, Munk C, Harris M, Pearce A, et al.
Nature
. 2020 Nov;
587(7835):650-656.
PMID: 33149304
G-protein-coupled receptors (GPCRs) are membrane proteins that modulate physiology across human tissues in response to extracellular signals. GPCR-mediated signalling can differ because of changes in the sequence or expression of...
10.
Veenith T, Pearce A
Int Arch Med
. 2008 May;
1(1):3.
PMID: 18471314
Introduction: Lactic acidosis often occurs in severely unwell patients presenting to Accident and Emergency. It is commonly associated with either hypoxia or decreased tissue perfusion secondary due to cardiovascular collapse...