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Abhyudai Singh

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Articles 140
Citations 2680
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Recent Articles
1.
Cross T, Torres F, McGee A, Aliyu T, Westblade L, Singh A, et al.
bioRxiv . 2025 Mar; PMID: 40027789
Antibiotic tolerance is the ability of bacteria to survive normally lethal doses of antibiotics for extended time periods. Clinically significant Enterobacterales, for example, often exhibit high tolerance to the last-resort...
2.
Guha M, Singh A, Butzin N
Commun Biol . 2025 Feb; 8(1):206. PMID: 39922941
Antibiotic resistant infections kill millions worldwide yearly. However, a key factor in recurrent infections is antibiotic persisters. Persisters are not inherently antibiotic-resistant but can withstand antibiotic exposure by entering a...
3.
Bokes P, Singh A
J Theor Biol . 2024 Nov; 598:111996. PMID: 39603338
Bacterial cell persistence, crucial for survival under adverse conditions like antibiotic exposure, is intrinsically linked to stochastic fluctuations in gene expression. Certain genes, while inhibiting growth under normal circumstances, confer...
4.
Rahman K, Amaratunga R, Butzin X, Singh A, Hossain T, Butzin N
Int J Antimicrob Agents . 2024 Nov; 65(1):107386. PMID: 39551274
Objectives: Bacterial persisters are a subpopulation of multidrug-tolerant cells capable of surviving and resuming activity after exposure to bactericidal antibiotic concentrations, contributing to relapsing infections and the development of antibiotic...
5.
Biswas K, Dey S, Singh A
Sci Rep . 2024 Nov; 14(1):27199. PMID: 39516495
Expressed gene products often interact ubiquitously with binding sites at nucleic acids and macromolecular complexes, known as decoys. The binding of transcription factors (TFs) to decoys can be crucial in...
6.
Celik C, Bokes P, Singh A
BMC Bioinformatics . 2024 Oct; 24(Suppl 1):493. PMID: 39438826
Background: Stochastic modelling plays a crucial role in comprehending the dynamics of intracellular events in various biochemical systems, including gene-expression models. Cell-to-cell variability arises from the stochasticity or noise in...
7.
Nieto C, Igler C, Singh A
bioRxiv . 2024 Oct; PMID: 39386733
Under stable growth conditions, bacteria maintain cell size homeostasis through coordinated elongation and division. However, fluctuations in nutrient availability result in dynamic regulation of the target cell size. Using microscopy...
8.
Bhattacharyya S, Lopez S, Singh A, Harshey R
Proc Natl Acad Sci U S A . 2024 Oct; 121(41):e2412541121. PMID: 39352926
Flagella are highly complex rotary molecular machines that enable bacteria to not only migrate to optimal environments but also to promote range expansion, competitiveness, virulence, and antibiotic survival. Flagellar motility...
9.
Nieto C, Vargas-Garcia C, Singh A
bioRxiv . 2024 Sep; PMID: 39345437
Measurements of cell size dynamics have revealed phenomenological principles by which individual cells control their size across diverse organisms. One of the emerging paradigms of cell size homeostasis is the...
10.
Petkidis A, Suomalainen M, Andriasyan V, Singh A, Greber U
mSphere . 2024 Sep; 9(10):e0045424. PMID: 39315811
Viruses display large variability across all stages of their life cycle, including entry, gene expression, replication, assembly, and egress. We previously reported that the immediate early adenovirus (AdV) E1A transcripts...