Aaron W Michels
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Explore the profile of Aaron W Michels including associated specialties, affiliations and a list of published articles.
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59
Citations
2081
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Recent Articles
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2.
Jia X, Wenzlau J, Zhang C, Dong F, Waugh K, Leslie R, et al.
Diabetes
. 2025 Jan;
PMID: 39821270
Increasing evidence shows that pathogenic T cells in type 1 diabetes (T1D) that may have evaded negative selection recognize post-translational modified (PTM) epitopes of self-antigens. We have investigated the profiles...
3.
Hanna S, Bonami R, Corrie B, Westley M, Posgai A, Luning Prak E, et al.
Diabetologia
. 2024 Oct;
68(1):186-202.
PMID: 39467874
Human molecular genetics has brought incredible insights into the variants that confer risk for the development of tissue-specific autoimmune diseases, including type 1 diabetes. The hallmark cell-mediated immune destruction that...
4.
Clinical Features and HLA Genetics Differ in Children at Type 1 Diabetes Onset by Hispanic Ethnicity
Karakus K, Fleury T, Baschal E, McDaniel K, Choi H, Armstrong T, et al.
J Clin Endocrinol Metab
. 2024 Sep;
PMID: 39231249
Context: Type 1 diabetes incidence continues to increase in children, especially among Hispanic Whites (HW). Objective: We investigated the clinical, immunologic, and genetic characteristics of HW and Non-Hispanic White (NHW)...
5.
Kasinathan D, Guo Z, Sarver D, Wong G, Yun S, Michels A, et al.
Diabetes
. 2024 Feb;
73(5):806-818.
PMID: 38387059
Article Highlights:
6.
Mitchell A, Baschal E, McDaniel K, Fleury T, Choi H, Pyle L, et al.
Sci Adv
. 2023 Dec;
9(49):eadj6975.
PMID: 38064552
T cells targeting self-proteins are important mediators in autoimmune diseases. T cells express unique cell-surface receptors (TCRs) that recognize peptides presented by major histocompatibility molecules. TCRs have been identified from...
7.
Jia X, Dong F, Pyle L, Michels A, Yu L, Rewers M
Diabetes Technol Ther
. 2023 Mar;
25(7):492-496.
PMID: 36989496
To assess whether the immunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines or breakthrough infection rates differ between patients with type 1 diabetes (T1D) and control subjects. A...
8.
Akturk H, Couts K, Baschal E, Karakus K, Van Gulick R, Turner J, et al.
JAMA Netw Open
. 2022 Dec;
5(12):e2246400.
PMID: 36512357
Importance: Treatment with immune checkpoint inhibitors (ICIs) has increased survival in patients with advanced malignant melanoma but can be associated with a wide range of immune-related adverse events (irAEs). The...
9.
Mitchell A, Baschal E, McDaniel K, Simmons K, Pyle L, Waugh K, et al.
JCI Insight
. 2022 Aug;
7(18).
PMID: 35998036
T cell receptor (TCR) sequences are exceptionally diverse and can now be comprehensively measured with next-generation sequencing technologies. However, a thorough investigation of longitudinal TCR repertoires throughout childhood in health...
10.
Mitchell A, Michels A
Int J Mol Sci
. 2022 Mar;
23(6).
PMID: 35328581
While progress has been made toward understanding mechanisms that lead to the development of autoimmunity, there is less knowledge regarding protective mechanisms from developing such diseases. For example, in type...