Aaron M Sargeant
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Explore the profile of Aaron M Sargeant including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
358
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Recent Articles
1.
Pardo I, Manno R, Capobianco R, Sargeant A, Morrison J, Bolon B, et al.
Toxicol Pathol
. 2021 Aug;
49(6):1140-1163.
PMID: 34423710
The use of minipigs as an alternative nonclinical species has increased in the last 20 years. The Society of Toxicologic Pathology (STP) has produced generic "best practice" recommendations for nervous...
2.
Rorabaugh B, Mabe N, Seeley S, Stoops T, Mucher K, Ney C, et al.
Stress
. 2019 Jul;
23(2):125-135.
PMID: 31347429
People who are exposed to life-threatening trauma are at risk of developing posttraumatic stress disorder (PTSD). In addition to psychological manifestations, PTSD is associated with an increased risk of myocardial...
3.
Tsai W, Bai L, Chen Y, Chu P, Hsu Y, Sargeant A, et al.
Oncotarget
. 2017 Apr;
8(17):29233-29246.
PMID: 28418923
Pancreatic cancer is an aggressive malignancy that is the fourth leading cause of death worldwide. Since there is a dire need for novel and effective therapies to improve the poor...
4.
Chiu C, Yang H, Yang M, Jeng L, Yang T, Sargeant A, et al.
Gastroenterol Res Pract
. 2016 Dec;
2016:6846027.
PMID: 27990157
Palliative gastrectomy has been suggested to improve survival of patients with metastatic gastric cancer, but limitations in study design and availability of robust prognostic factors have cast doubt on the...
5.
Chiu C, Weng J, Jadhav A, Wu C, Sargeant A, Bai L
Int J Mol Sci
. 2016 Aug;
17(8).
PMID: 27537872
T315, an integrin-linked kinase (ILK) inhibitor, has been shown to suppress the proliferation of breast cancer, stomach cancer and chronic lymphocytic leukemia cells. Here we demonstrate that T315 decreases cell...
6.
Chiu C, Yang H, Yang M, Jeng L, Sargeant A, Yeh S, et al.
Springerplus
. 2016 Jul;
5(1):728.
PMID: 27375997
Background: The influence of adjuvant chemotherapy on the survival of gastric adenocarcinoma patients in a stage-specific manner is controversial. Methods: To further explore this topic, we retrospectively analyzed the impact...
7.
Helke K, Nelson K, Sargeant A, Jacob B, McKeag S, Haruna J, et al.
Toxicol Pathol
. 2016 Apr;
44(4):575-90.
PMID: 27044377
Both a rodent and a nonrodent species are required for evaluation in nonclinical safety studies conducted to support human clinical trials. Historically, dogs and nonhuman primates have been the nonrodent...
8.
Bai L, Chiu C, Kapuriya N, Shieh T, Tsai Y, Wu C, et al.
Eur J Pharmacol
. 2015 Nov;
769:287-96.
PMID: 26607461
TANK-binding kinase 1 (TBK1), a member of IκB Kinase (IKK)-related kinases, plays a role in regulating innate immunity, inflammation and oncogenic signaling. This study aims to investigate the role of...
9.
Helke K, Nelson K, Sargeant A, Jacob B, McKeag S, Haruna J, et al.
Toxicol Pathol
. 2015 Nov;
44(3):325-37.
PMID: 26534940
Swine, especially the miniature swine or minipigs, are increasingly being used in preclinical safety assessment of small molecules, biopharmaceutical agents, and medical devices as an alternate nonrodent species. Although swine...
10.
Chen T, Chiu C, Yang T, Lin C, Sargeant A, Yeh S, et al.
Leuk Res
. 2014 Dec;
39(2):151-6.
PMID: 25524176
The influence of hepatitis C virus (HCV) infection on the outcome of patients with diffuse large B cell lymphoma (DLBCL) treated with rituximab-based chemotherapy is controversial. We retrospectively analyzed the...