Aaron M Coffey
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Explore the profile of Aaron M Coffey including associated specialties, affiliations and a list of published articles.
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48
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1759
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Recent Articles
1.
Birchall J, Coffey A, Goodson B, Chekmenev E
Anal Chem
. 2020 Nov;
92(23):15280-15284.
PMID: 33170640
We present an automated parahydrogen generator (ParaSun) for clinical-scale applications in parahydrogen-induced polarization (PHIP) and signal amplification by reversible exchange (SABRE) at high pressures. The device employs a vacuum-pumped, Sunpower...
2.
Birchall J, Irwin R, Nikolaou P, Coffey A, Kidd B, Murphy M, et al.
J Magn Reson
. 2020 Sep;
319:106813.
PMID: 32932118
We present a second-generation open-source automated batch-mode Xe hyperpolarizer (XeUS GEN-2), designed for clinical-scale hyperpolarized (HP) Xe production via spin-exchange optical pumping (SEOP) in the regimes of high Xe density...
3.
Birchall J, Nikolaou P, Irwin R, Barlow M, Ranta K, Coffey A, et al.
J Magn Reson
. 2020 May;
315:106739.
PMID: 32408239
We present studies of spin-exchange optical pumping (SEOP) using ternary xenon-nitrogen-helium gas mixtures at high xenon partial pressures (up to 1330 Torr partial pressure at loading, out of 2660 Torr...
4.
Birchall J, Nikolaou P, Coffey A, Kidd B, Murphy M, Molway M, et al.
Anal Chem
. 2020 Feb;
92(6):4309-4316.
PMID: 32073251
We present spin-exchange optical pumping (SEOP) using a third-generation (GEN-3) automated batch-mode clinical-scale Xe hyperpolarizer utilizing continuous high-power (∼170 W) pump laser irradiation and a novel aluminum jacket design for...
5.
Skinner J, Ranta K, Whiting N, Coffey A, Nikolaou P, Rosen M, et al.
J Magn Reson
. 2020 Feb;
312:106686.
PMID: 32006793
Spin-exchange optical pumping (SEOP) can enhance the NMR sensitivity of noble gases by up to five orders of magnitude at Tesla-strength magnetic fields. SEOP-generated hyperpolarised (HP) Xe is a promising...
6.
Bales L, Kovtunov K, Barskiy D, Shchepin R, Coffey A, Kovtunova L, et al.
J Phys Chem C Nanomater Interfaces
. 2017 Dec;
121(28):15304-15309.
PMID: 29238438
The successful transfer of parahydrogen-induced polarization to N spins using heterogeneous catalysts in aqueous solutions was demonstrated. Hydrogenation of a synthesized unsaturated N-labeled precursor (neurine) with parahydrogen (p-H) over Rh/TiO...
7.
Coffey A, Shchepin R, Feng B, Colon R, Wilkens K, Waddell K, et al.
J Magn Reson
. 2017 Oct;
284:115-124.
PMID: 29028543
Applications of parahydrogen induced polarization (PHIP) often warrant conversion of the chemically-synthesized singlet-state spin order into net heteronuclear magnetization. In order to obtain optimal yields from the overall hyperpolarization process,...
8.
Coffey A, Feldman M, Shchepin R, Barskiy D, Truong M, Pham W, et al.
J Magn Reson
. 2017 Jun;
281:246-252.
PMID: 28651245
High-resolution C NMR spectroscopy of hyperpolarized succinate-1-C-2,3-d is reported in vitro and in vivo using a clinical-scale, biplanar (80cm-gap) 48.7mT permanent magnet with a high homogeneity magnetic field. Non-localized C...
9.
Barskiy D, Salnikov O, Romanov A, Feldman M, Coffey A, Kovtunov K, et al.
J Magn Reson
. 2017 Feb;
276:78-85.
PMID: 28152435
When parahydrogen reacts with propylene in low magnetic fields (e.g., 0.05T), the reaction product propane develops an overpopulation of pseudo-singlet nuclear spin states. We studied how the Spin-Lock Induced Crossing...
10.
Barskiy D, Salnikov O, Shchepin R, Feldman M, Coffey A, Kovtunov K, et al.
J Phys Chem C Nanomater Interfaces
. 2017 Jan;
120(51):29098-29106.
PMID: 28066517
Parahydrogen-induced polarization (PHIP) is an NMR hyperpolarization technique that increases nuclear spin polarization by orders of magnitude, and it is particularly well-suited to study hydrogenation reactions. However, the use of...