Aaron M Coffey
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Explore the profile of Aaron M Coffey including associated specialties, affiliations and a list of published articles.
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48
Citations
1759
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Recent Articles
11.
Barskiy D, Coffey A, Nikolaou P, Mikhaylov D, Goodson B, Branca R, et al.
Chemistry
. 2016 Oct;
23(4):725-751.
PMID: 27711999
Nuclear spin polarization can be significantly increased through the process of hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance (NMR) experiments by 4-8 orders of magnitude....
12.
Shchepin R, Barskiy D, Coffey A, Goodson B, Chekmenev E
ChemistrySelect
. 2016 Aug;
1(10):2552-2555.
PMID: 27500206
NMR hyperpolarization via Signal Amplification by Reversible Exchange (SABRE) was employed to investigate the feasibility of enhancing the NMR detection sensitivity of sulfur-heterocycles (specifically 2-methylthiophene and dibenzothiophenes), a family of...
13.
Coffey A, Shchepin R, Truong M, Wilkens K, Pham W, Chekmenev E
Anal Chem
. 2016 Aug;
88(16):8279-88.
PMID: 27478927
An open-source hyperpolarizer producing (13)C hyperpolarized contrast agents using parahydrogen induced polarization (PHIP) for biomedical and other applications is presented. This PHIP hyperpolarizer utilizes an Arduino microcontroller in conjunction with...
14.
Salnikov O, Barskiy D, Coffey A, Kovtunov K, Koptyug I, Chekmenev E
Chemphyschem
. 2016 Jul;
17(21):3395-3398.
PMID: 27459542
We report on a simple approach for efficient NMR proton hyperpolarization of propane using the parahydrogen-induced polarization (PHIP) technique, which yielded ≈6.2 % proton polarization using ≈80 % parahydrogen, a...
15.
Shchepin R, Barskiy D, Coffey A, Theis T, Shi F, Warren W, et al.
ACS Sens
. 2016 Jul;
1(6):640-644.
PMID: 27379344
N nuclear spins of imidazole-N were hyperpolarized using NMR signal amplification by reversible exchange in shield enables alignment transfer to heteronuclei (SABRE-SHEATH). A N NMR signal enhancement of ∼2000-fold at...
16.
Aqueous NMR Signal Enhancement by Reversible Exchange in a Single Step Using Water-Soluble Catalysts
Shi F, He P, Best Q, Groome K, Truong M, Coffey A, et al.
J Phys Chem C Nanomater Interfaces
. 2016 Jun;
120(22):12149-12156.
PMID: 27350846
Two synthetic strategies are investigated for the preparation of water-soluble iridium-based catalysts for NMR signal amplification by reversible exchange (SABRE). In one approach, PEGylation of a variant -heterocyclic carbene provided...
17.
Barskiy D, Shchepin R, Coffey A, Theis T, Warren W, Goodson B, et al.
J Am Chem Soc
. 2016 Jun;
138(26):8080-3.
PMID: 27321159
Direct NMR hyperpolarization of naturally abundant (15)N sites in metronidazole is demonstrated using SABRE-SHEATH (Signal Amplification by Reversible Exchange in SHield Enables Alignment Transfer to Heteronuclei). In only a few...
18.
Shchepin R, Barskiy D, Coffey A, Manzanera Esteve I, Chekmenev E
Angew Chem Int Ed Engl
. 2016 Apr;
55(20):6071-4.
PMID: 27061815
A scalable and versatile methodology for production of vinylated carboxylic compounds with (13) C isotopic label in C1 position is described. It allowed synthesis of vinyl acetate-1-(13) C, which is...
19.
Shi F, Coffey A, Waddell K, Chekmenev E, Goodson B
J Phys Chem C Nanomater Interfaces
. 2015 Jul;
119(13):7525-7533.
PMID: 26185545
Two types of nanoscale catalysts were created to explore NMR signal enhancement via reversible exchange (SABRE) at the interface between heterogeneous and homogeneous conditions. Nanoparticle and polymer comb variants were...
20.
Shchepin R, Truong M, Theis T, Coffey A, Shi F, Waddell K, et al.
J Phys Chem Lett
. 2015 Jun;
6(10):1961-7.
PMID: 26029349
We report NMR Signal Amplification by Reversible Exchange (SABRE) hyperpolarization of the rare isotopes in "neat" liquids, each composed only of an otherwise pure target compound with isotopic natural abundance...