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Aaron L Fidler

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Articles 7
Citations 232
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Recent Articles
1.
Page-McCaw P, Pokidysheva E, Darris C, Chetyrkin S, Fidler A, Gallup J, et al.
bioRxiv . 2023 Oct; PMID: 37905027
Collagen IV is a major component of basement membranes, a specialized form of extracellular matrix that enabled the assembly of multicellular epithelial tissues. In mammals, collagen IV assembles from a...
2.
Boudko S, Pedchenko V, Pokidysheva E, Budko A, Baugh R, Coates P, et al.
J Biol Chem . 2023 Oct; 299(11):105318. PMID: 37797699
Collagen IV scaffold is a primordial innovation enabling the assembly of a fundamental architectural unit of epithelial tissues-a basement membrane attached to polarized cells. A family of six α-chains (α1...
3.
Pokidysheva E, Seeger H, Pedchenko V, Chetyrkin S, Bergmann C, Abrahamson D, et al.
J Biol Chem . 2021 Mar; 296:100590. PMID: 33774048
Diseases of the glomerular basement membrane (GBM), such as Goodpasture's disease (GP) and Alport syndrome (AS), are a major cause of chronic kidney failure and an unmet medical need. Collagen...
4.
Pedchenko V, Bauer R, Pokidysheva E, Al-Shaer A, Forde N, Fidler A, et al.
J Biol Chem . 2019 Mar; 294(20):7968-7981. PMID: 30923125
Collagen IV scaffold is a principal component of the basement membrane (BM), a specialized extracellular matrix that is essential for animal multicellularity and tissue evolution. Scaffold assembly begins with the...
5.
Fidler A, Boudko S, Rokas A, Hudson B
J Cell Sci . 2018 Apr; 131(7). PMID: 29632050
The cellular microenvironment, characterized by an extracellular matrix (ECM), played an essential role in the transition from unicellularity to multicellularity in animals (metazoans), and in the subsequent evolution of diverse...
6.
Fidler A, Darris C, Chetyrkin S, Pedchenko V, Boudko S, Brown K, et al.
Elife . 2017 Apr; 6. PMID: 28418331
The role of the cellular microenvironment in enabling metazoan tissue genesis remains obscure. Ctenophora has recently emerged as one of the earliest-branching extant animal phyla, providing a unique opportunity to...
7.
Fidler A, Vanacore R, Chetyrkin S, Pedchenko V, Bhave G, Yin V, et al.
Proc Natl Acad Sci U S A . 2013 Dec; 111(1):331-6. PMID: 24344311
Basement membrane, a specialized ECM that underlies polarized epithelium of eumetazoans, provides signaling cues that regulate cell behavior and function in tissue genesis and homeostasis. A collagen IV scaffold, a...