Aaron J Schmitz
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Explore the profile of Aaron J Schmitz including associated specialties, affiliations and a list of published articles.
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44
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3450
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Recent Articles
1.
Lopatto E, Santiago-Borges J, Sanick D, Malladi S, Azimzadeh P, Timm M, et al.
bioRxiv
. 2024 Dec;
PMID: 39713358
As antimicrobial resistance increases, urinary tract infections (UTIs) are expected to pose an increased burden in morbidity and expense on the healthcare system, increasing the need for alternative antibiotic-sparing treatments....
2.
Malladi S, Jaiswal D, Ying B, Alsoussi W, Darling T, Dadonaite B, et al.
bioRxiv
. 2024 Dec;
PMID: 39713327
SARS-CoV-2 mRNA vaccines induce robust and persistent germinal centre (GC) B cell responses in humans. It remains unclear how the continuous evolution of the virus impacts the breadth of the...
3.
Matz H, Yu T, Zhou J, Peyton L, Madsen A, Han F, et al.
bioRxiv
. 2024 Oct;
PMID: 39416092
Eliciting broad and durable antibody responses against rapidly evolving pathogens like influenza viruses remains a formidable challenge. The germinal center (GC) reaction enables the immune system to generate broad, high-affinity,...
4.
Borcherding N, Kim W, Quinn M, Han F, Zhou J, Sturtz A, et al.
Nat Immunol
. 2024 Aug;
25(9):1731-1741.
PMID: 39164479
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mRNA vaccination induce robust CD4 T cell responses. Using single-cell transcriptomics, here, we evaluated CD4 T cells specific for the SARS-CoV-2...
5.
Schattgen S, Turner J, Ghonim M, Crawford J, Schmitz A, Kim H, et al.
Nat Immunol
. 2024 Aug;
25(9):1742-1753.
PMID: 39164477
The differentiation and specificity of human CD4 T follicular helper cells (T cells) after influenza vaccination have been poorly defined. Here we profiled blood and draining lymph node (LN) samples...
6.
McIntire K, Meng H, Lin T, Kim W, Moore N, Han J, et al.
J Exp Med
. 2024 Jun;
221(8).
PMID: 38935072
Germinal centers (GC) are microanatomical lymphoid structures where affinity-matured memory B cells and long-lived bone marrow plasma cells are primarily generated. It is unclear how the maturation of B cells...
7.
Lei R, Kim W, Lv H, Mou Z, Scherm M, Schmitz A, et al.
Immunity
. 2023 Nov;
56(11):2621-2634.e6.
PMID: 37967533
There is growing appreciation for neuraminidase (NA) as an influenza vaccine target; however, its antigenicity remains poorly characterized. In this study, we isolated three broadly reactive N2 antibodies from the...
8.
Schattgen S, Turner J, Ghonim M, Crawford J, Schmitz A, Kim H, et al.
bioRxiv
. 2023 Sep;
PMID: 37693531
We profiled blood and draining lymph node (LN) samples from human volunteers after influenza vaccination over two years to define evolution in the T follicular helper cell (TFH) response. We...
9.
Hansen L, McMahon M, Turner H, Zhu X, Turner J, Ozorowski G, et al.
Immunity
. 2023 Jul;
56(8):1927-1938.e8.
PMID: 37506693
Neuraminidase (NA) is one of the two influenza virus surface glycoproteins, and antibodies that target it are an independent correlate of protection. However, our current understanding of NA antigenicity is...
10.
Alsoussi W, Malladi S, Zhou J, Liu Z, Ying B, Kim W, et al.
Nature
. 2023 Apr;
617(7961):592-598.
PMID: 37011668
The primary two-dose SARS-CoV-2 mRNA vaccine series are strongly immunogenic in humans, but the emergence of highly infectious variants necessitated additional doses and the development of vaccines aimed at the...