Aaron G Schmidt
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Explore the profile of Aaron G Schmidt including associated specialties, affiliations and a list of published articles.
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102
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Recent Articles
1.
Maurer D, Vu M, Schmidt A
Immunity
. 2025 Mar;
58(3):716-727.e6.
PMID: 40023162
Initial exposure to a rapidly evolving virus establishes B cell memory that biases later responses to antigenically drifted strains. This "immune imprinting" implies that subsequent exposure to a drifted strain...
2.
Gutierrez-Gonzalez M, Fahad A, Delley C, Chung C, Jin S, Boyle N, et al.
bioRxiv
. 2025 Feb;
PMID: 39975077
Neutralizing antibodies provide rapid immune defense against infectious diseases, but are difficult to discover at scale because neutralization assays require live reporter cells and soluble monoclonal antibodies. Here we report...
3.
Feldman J, Ramos A, Vu M, Maurer D, Rosado V, Lingwood D, et al.
Sci Immunol
. 2025 Jan;
10(103):eado9572.
PMID: 39854479
Understanding the naïve B cell repertoire and its specificity for potential zoonotic threats, such as the highly pathogenic avian influenza (HPAI) H5Nx viruses, may allow prediction of infection- or vaccine-specific...
4.
Case J, Sanapala S, Dillen C, Rhodes V, Zmasek C, Chicz T, et al.
Cell Host Microbe
. 2024 Nov;
32(12):2131-2147.e8.
PMID: 39561781
The continued emergence of SARS-CoV-2 variants and the threat of future Sarbecovirus zoonoses have spurred the design of vaccines that can induce broad immunity against multiple coronaviruses. Here, we use...
5.
Maurer D, Vu M, Ramos A, Dugan H, Khalife P, Geoghegan J, et al.
bioRxiv
. 2024 Nov;
PMID: 39484545
Monoclonal antibodies (mAbs) targeting the influenza hemagglutinin (HA) have the potential to be used as prophylactics or templates for next-generation vaccines that provide broad protection. Here, we isolated broad, subtype-neutralizing...
6.
Roffler A, Maurer D, Lunn T, Sironen T, Forbes K, Schmidt A
Front Immunol
. 2024 Aug;
15:1269760.
PMID: 39156901
Bats harbor viruses that can cause severe disease and death in humans including filoviruses (e.g., Ebola virus), henipaviruses (e.g., Hendra virus), and coronaviruses (e.g., SARS-CoV). Bats often tolerate these viruses...
7.
Ray R, Nait Mohamed F, Maurer D, Huang J, Alpay B, Ronsard L, et al.
Immunity
. 2024 Apr;
57(5):1141-1159.e11.
PMID: 38670113
Broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin (HA) stem of influenza A viruses (IAVs) tend to be effective against either group 1 or group 2 viral diversity. In rarer cases,...
8.
Jacob-Dolan C, Lifton M, Powers O, Miller J, Hachmann N, Vu M, et al.
iScience
. 2024 Apr;
27(5):109716.
PMID: 38655202
The viral vector-based COVID-19 vaccine Ad26.COV2.S has been recommended by the WHO since 2021 and has been administered to over 200 million people. Prior studies have shown that Ad26.COV2.S induces...
9.
Deng Y, Tang M, Ross T, Schmidt A, Chakraborty A, Lingwood D
medRxiv
. 2024 Apr;
PMID: 38585939
The on-going diversification of influenza virus necessicates annual vaccine updating. The vaccine antigen, the viral spike protein hemagglutinin (HA), tends to elicit strain-specific neutralizing activity, predicting that sequential immunization with...
10.
Maurer D, Vu M, Schmidt A
bioRxiv
. 2024 Apr;
PMID: 38562862
An initial virus exposure can imprint antibodies such that future responses to antigenically drifted strains are dependent on the identity of the imprinting strain. Subsequent exposure to antigenically distinct strains...