A P Osterop
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Explore the profile of A P Osterop including associated specialties, affiliations and a list of published articles.
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7
Citations
57
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Recent Articles
1.
Danser A, Deinum J, Osterop A, Admiraal P, SCHALEKAMP M
J Hypertens
. 2000 Mar;
17(12 Pt 2):1867-72.
PMID: 10703882
Objective: The angiotensin-converting enzyme (ACE) gene I/D polymorphism accounts for part of the variation in ACE concentration; subjects with one or two D alleles have approximately 25 and 50% higher...
2.
Osterop A, Kofflard M, Sandkuijl L, Ten Cate F, Krams R, SCHALEKAMP M, et al.
Hypertension
. 1998 Nov;
32(5):825-30.
PMID: 9822439
The development of left ventricular hypertrophy (LVH) in subjects with hypertrophic cardiomyopathy (HCM) is variable, suggesting a role for modifying factors such as angiotensin II. We investigated whether the angiotensin...
3.
Osterop A, Medema R, Ouwens D, van der Zon G, Moller W, Maassen J
Biochemistry
. 1994 Jun;
33(23):7453-9.
PMID: 8003510
Activated receptors with a tyrosine kinase activity induce a variety of responses like changes in the differentiation and mitogenic status of cells. These responses are mediated in part by p21ras....
4.
Osterop A, Medema R, vd Zon G, Bos J, Moller W, Maassen J
Eur J Biochem
. 1993 Mar;
212(2):477-82.
PMID: 8444185
Activation of the Ras proto-oncogene contributes in general to mitogenic activation of cells. We show here that epidermal growth factor (EGF) stimulates Ras.GTP formation very efficiently in a variety of...
5.
Osterop A, Medema R, Bos J, vd Zon G, Moller D, Flier J, et al.
J Biol Chem
. 1992 Jul;
267(21):14647-53.
PMID: 1634512
We showed previously that upon insulin stimulation of an insulin receptor overexpressing cell line, most of the p21ras was rapidly converted into the GTP bound state (Burgering, B. M. T.,...
6.
Maassen J, Burgering B, Medema R, Osterop A, van der Zon G, Moller W, et al.
Horm Metab Res
. 1992 May;
24(5):214-8.
PMID: 1398459
Ras-proteins are guanine nucleotide binding proteins, which, in the GTP bound state emit a strong mitogenic signal. In the GDP bound state, the protein appears inactive. We have found that...
7.
Weenen H, Osterop A, Van der Poort S, Lankelma J, van der Vijgh W, Pinedo H
J Pharm Sci
. 1986 Dec;
75(12):1201-4.
PMID: 3470504
An analytical method based on isocratic HPLC separation and fluorescence detection was developed to allow for sensitive and specific analysis of anthracyclines and their metabolites in plasma and urine. The...