A O Grant
Overview
Explore the profile of A O Grant including associated specialties, affiliations and a list of published articles.
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81
Citations
877
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Recent Articles
1.
Grant A
Trends Cardiovasc Med
. 2011 Jan;
1(8):321-30.
PMID: 21239287
Conduction in most regions of the heart is sustained by transient increases in membrane permeability to Na(+). The application of contemporary biophysical and molecular biologic techniques demonstrates that permeability to...
2.
Carboni M, Zhang Z, Neplioueva V, Starmer C, Grant A
J Membr Biol
. 2006 Feb;
207(2):107-17.
PMID: 16477531
Voltage- and/or conformation-dependent association and dissociation of local anesthetic-class drugs from a putative receptor site in domain IV S6 of the sodium channel and slow conformation transitions of the drug-associated...
3.
Starmer C, Grant A, Colatsky T
Cardiovasc Res
. 2003 Mar;
57(4):1062-71.
PMID: 12650884
Objective: The fate of an impulse arising from stimulation is determined by the ability of the wave front to recruit sufficient Na channels from adjacent cells. Previous numerical studies of...
4.
Link M, Antzelevitch C, Waldo A, Grant A, DiMarco J, Josephson M, et al.
J Cardiovasc Electrophysiol
. 2002 Jan;
12(12):1433-43.
PMID: 11798006
No abstract available.
5.
Grant A
Am J Med
. 2001 Mar;
110(4):296-305.
PMID: 11239848
The sodium channel is an integral membrane protein that plays a central role in conduction of the cardiac impulse in working cardiac myocytes and cells of the His-Purkinje system. The...
6.
Grant A, Chandra R, Keller C, Carboni M, Starmer C
Biophys J
. 2000 Dec;
79(6):3019-35.
PMID: 11106609
The role of inactivation as a central mechanism in blockade of the cardiac Na(+) channel by antiarrhythmic drugs remains uncertain. We have used whole-cell and single channel recordings to examine...
7.
Chauhan V, Tuvia S, Buhusi M, Bennett V, Grant A
Circ Res
. 2000 Mar;
86(4):441-7.
PMID: 10700449
The cytoskeleton of the cardiomyocyte has been shown to modulate ion channel function. Cytoskeletal disruption in vitro alters Na(+) channel kinetics, producing a late Na(+) current that can prolong repolarization....
8.
Chandra R, Chauhan V, Starmer C, Grant A
Cardiovasc Res
. 1999 Oct;
42(2):490-502.
PMID: 10533584
Objective: Prior studies of the modulation of the Na+ current by sympathetic stimulation have yielded controversial results. Separation of the Na+ and Ca2+ currents poses a problem in myocyte preparations....
9.
Grant A
Am J Cardiol
. 1998 Nov;
82(8A):43N-49N.
PMID: 9809900
Drugs remain the mainstay of treatment of patients with atrial fibrillation (AF). An understanding of the mechanisms of AF and of atrioventricular (AV) conduction provides a basis for the understanding...
10.
Chandra R, Starmer C, Grant A
Am J Physiol
. 1998 Jun;
274(5):H1643-54.
PMID: 9612375
Several aspects of the effect of the KPQ deletion mutation on Na+ channel gating remain unresolved. We have analyzed the kinetics of the early and late currents by recording whole...