A Nussenzweig
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Explore the profile of A Nussenzweig including associated specialties, affiliations and a list of published articles.
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25
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1221
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Recent Articles
1.
van de Kooij B, Schreuder A, Pavani R, Garzero V, Van Hoeck A, San Martin Alonso M, et al.
bioRxiv
. 2023 Sep;
PMID: 37720033
Deficiency for the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR) leads to chromosomal instability and diseases such as cancer. Yet, defective HR also results in vulnerabilities that...
2.
Callen E, Nussenzweig M, Nussenzweig A
Oncogene
. 2007 Dec;
26(56):7759-64.
PMID: 18066088
Double-strand breaks (DSBs) are intermediates in several physiological processes including V(D)J and class switch recombination. They are also potent substrates for chromosomal translocations that arise as by-products of antigen receptor...
3.
Davodeau F, Difilippantonio M, Roldan E, Malissen M, Casanova J, Couedel C, et al.
EMBO J
. 2001 Sep;
20(17):4717-29.
PMID: 11532936
The T-cell receptor (TCR) alpha locus is thought to undergo multiple cycles of secondary rearrangements that maximize the generation of alphabeta T cells. Taking advantage of the nucleotide sequence of...
4.
Yannoutsos N, Wilson P, Yu W, Chen H, Nussenzweig A, Petrie H, et al.
J Exp Med
. 2001 Aug;
194(4):471-80.
PMID: 11514603
Assembly of T cell receptor (TCR)alpha/beta genes by variable/diversity/joining (V[D]J) rearrangement is an ordered process beginning with recombination activating gene (RAG) expression and TCRbeta recombination in CD4(-)CD8(-)CD25(+) thymocytes. In these...
5.
Sekiguchi J, Ferguson D, Chen H, Yang E, Earle J, Frank K, et al.
Proc Natl Acad Sci U S A
. 2001 Mar;
98(6):3243-8.
PMID: 11248063
DNA ligase IV (Lig4) and the DNA-dependent protein kinase (DNA-PK) function in nonhomologous end joining (NHEJ). However, although Lig4 deficiency causes late embryonic lethality, deficiency in DNA-PK subunits (Ku70, Ku80,...
6.
Zhu J, Petersen S, Tessarollo L, Nussenzweig A
Curr Biol
. 2001 Mar;
11(2):105-9.
PMID: 11231126
Nijmegen breakage syndrome (NBS) is a rare autosomal recessive human disease whose clinical features include growth retardation, immunodeficiency, and increased susceptibility to lymphoid malignancies. Cells from NBS patients exhibit gamma-irradiation...
7.
Arrington E, Caldwell M, Kumaravel T, Lohani A, Joshi A, Evans M, et al.
Free Radic Biol Med
. 2000 Dec;
29(11):1166-76.
PMID: 11121725
While the Ku complex, comprised of Ku70 and Ku80, is primarily involved in the repair of DNA double-strand breaks, it is also believed to participate in additional cellular processes. Here,...
8.
Chen H, Bhandoola A, Difilippantonio M, Zhu J, Brown M, Tai X, et al.
Science
. 2000 Dec;
290(5498):1962-5.
PMID: 11110662
Genetic disorders affecting cellular responses to DNA damage are characterized by high rates of translocations involving antigen receptor loci and increased susceptibility to lymphoid malignancies. We report that the Nijmegen...
9.
Bhandoola A, DOLNICK B, Fayad N, Nussenzweig A, Singer A
J Exp Med
. 2000 Sep;
192(6):891-7.
PMID: 10993919
Immature CD4(+)CD8(+) thymocytes rearrange their T cell receptor (TCR)-alpha gene locus to generate clonotypic alpha/beta TCR, after which a few cells expressing selectable TCR are signaled to further differentiate into...
10.
Difilippantonio M, Zhu J, Chen H, Meffre E, Nussenzweig M, Max E, et al.
Nature
. 2000 Apr;
404(6777):510-4.
PMID: 10761921
Cancer susceptibility genes have been classified into two groups: gatekeepers and caretakers. Gatekeepers are genes that control cell proliferation and death, whereas caretakers are DNA repair genes whose inactivation leads...