A Leask
Overview
Explore the profile of A Leask including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
28
Citations
887
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0
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Recent Articles
1.
Rock L, Akade G, Al-Waeli H, Allin S, Altabtbaei K, Ameli N, et al.
J Dent Res
. 2024 Dec;
104(2):113-118.
PMID: 39698820
Recent years have seen significant positive changes and developments in oral health-related policy and data on oral health and oral health care in Canada. Simultaneously, on the international stage, the...
2.
Sharma M, Fadl A, Leask A
J Dent Res
. 2024 May;
103(7):689-696.
PMID: 38779873
Scleroderma (systemic sclerosis, SSc) is an autoimmune fibrosing connective tissue disease of unknown etiology. SSc patients show increased levels of autoantibodies, profibrotic cytokines, and extracellular matrix remodeling enzymes that collectively...
3.
4.
Perbal B, Trackman P, Castellot J, Brigstock D, Takigawa M, Lau L, et al.
J Cell Commun Signal
. 2014 Feb;
8(1):71-6.
PMID: 24553917
In this report, chairs of the 7th International Workshop on the CCN family of Genes, review the progress made in understanding the biological functions of CCN proteins (CCN1, CCN2, CCN3,...
5.
Fajardo O, Thompson K, Parapuram S, Liu S, Leask A
Cell Prolif
. 2011 Mar;
44(2):166-73.
PMID: 21401758
Fibrosis is characterized by loss of normal structure and function of a tissue or organ resulting from excessive fibroblast proliferation and extracellular matrix production. Currently, there is no efficient treatment...
6.
Riopel M, Krishnamurthy M, Li J, Liu S, Leask A, Wang R
J Pathol
. 2011 Mar;
224(1):45-55.
PMID: 21381031
β1-Integrin, a critical regulator of β cell survival and function, has been shown to protect against cell death and promote insulin expression and secretion in rat and human islet cells...
7.
Thompson K, Hamilton D, Leask A
J Dent Res
. 2010 Oct;
89(12):1450-4.
PMID: 20924066
Connective tissue growth factor (CCN2/CTGF) is not normally expressed in gingival fibroblasts, but is induced by the potent profibrotic cytokine TGFβ and is overexpressed in gingival fibrosis. Since CCN2 is...
8.
Shiwen X, Leask A, Abraham D, Fonseca C
Eur J Clin Invest
. 2009 Apr;
39 Suppl 2:19-26.
PMID: 19335743
Scleroderma [systemic sclerosis (SSc)] is a spectrum of connective tissue diseases characterized by micro- and macro-vasculopathy, inflammation and autoimmunity and tissue remodelling that often leads to excessive scarring and fibrosis...
9.
Aden N, Shiwen X, Aden D, Black C, Nuttall A, Denton C, et al.
Rheumatology (Oxford)
. 2008 Oct;
47(12):1754-60.
PMID: 18829709
Objective: To identify using proteomic analysis, proteins of altered abundance in the skin of patients with SSc. Methods: 4 mm excision biopsies were obtained from the forearm involved skin of...
10.
Woods A, Pala D, Kennedy L, McLean S, Rockel J, Wang G, et al.
Osteoarthritis Cartilage
. 2008 Sep;
17(3):406-13.
PMID: 18760941
Objective: Connective tissue growth factor (CTGF) has been implicated in regulation of chondrocyte differentiation at multiple steps and has been implicated in the progression of diseases such as scleroderma and...