A L Hubbard
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Explore the profile of A L Hubbard including associated specialties, affiliations and a list of published articles.
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89
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3203
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Recent Articles
1.
Bougamont M, Christoffersen P, Hubbard A, Fitzpatrick A, Doyle S, Carter S
Nat Commun
. 2014 Sep;
5:5052.
PMID: 25262753
The dynamic response of the Greenland Ice Sheet (GrIS) depends on feedbacks between surface meltwater delivery to the subglacial environment and ice flow. Recent work has highlighted an important role...
2.
Braiterman L, Nyasae L, Leves F, Hubbard A
Am J Physiol Gastrointest Liver Physiol
. 2011 Apr;
301(1):G69-81.
PMID: 21454443
ATP7A and ATP7B are copper-transporting P-type ATPases that are essential to eukaryotic copper homeostasis and must traffic between intracellular compartments to carry out their functions. Previously, we identified a nine-amino...
3.
Donowitz M, Singh S, Singh P, Chakraborty M, Chen Y, Murtazina R, et al.
Physiol Genomics
. 2011 Mar;
43(11):674-84.
PMID: 21427361
To identify additional potential functions for the multi-PDZ domain containing protein Na+/H+ exchanger regulatory factor 2 (NHERF2), which is present in the apical domain of intestinal epithelial cells, proteomic studies...
4.
Donowitz M, Singh S, Singh P, Salahuddin F, Chen Y, Chakraborty M, et al.
Physiol Genomics
. 2010 Aug;
42A(3):200-10.
PMID: 20736413
Na/H exchanger regulatory factor 1 (NHERF1) is a scaffold protein made up of two PDZ domains and an ERM binding domain. It is in the brush border of multiple epithelial...
5.
Tuma P, Hubbard A
Curr Protoc Cell Biol
. 2008 Jan;
Chapter 3:Unit 3.2.
PMID: 18228354
This unit describes a method for isolation of plasma membrane sheets from rat liver. It also includes protocols for preparation of plasma membrane domains isolated from plasma membrane sheets and...
6.
Guo Y, Nyasae L, Braiterman L, Hubbard A
Am J Physiol Gastrointest Liver Physiol
. 2005 Jul;
289(5):G904-16.
PMID: 15994426
Cu is an essential cofactor of cellular proteins but is toxic in its free state. The hepatic Cu-ATPase ATP7B has two functions in Cu homeostasis: it loads Cu+ onto newly...
7.
Akhter S, Kovbasnjuk O, Li X, Cavet M, Noel J, Arpin M, et al.
Am J Physiol Cell Physiol
. 2002 Aug;
283(3):C927-40.
PMID: 12176749
Cell biological approaches were used to examine the location and function of the brush border (BB) Na(+)/H(+) exchanger NHE3 in the opossum kidney (OK) polarized renal proximal tubule cell line....
8.
Bastaki M, Braiterman L, Johns D, Chen Y, Hubbard A
Mol Biol Cell
. 2002 Jan;
13(1):225-37.
PMID: 11809835
The absence of a direct route to the apical plasma membrane (PM) for single transmembrane domain (TMD) proteins in polarized hepatic cells has been inferred but never directly demonstrated. The...
9.
Bustos R, Kolen E, Braiterman L, Baines A, Gorelick F, Hubbard A
J Cell Sci
. 2001 Nov;
114(Pt 20):3695-704.
PMID: 11707521
Synapsin I is abundant in neural tissues. Its phosphorylation is thought to regulate synaptic vesicle exocytosis in the pre-synaptic terminal by mediating vesicle tethering to the cytoskeleton. Using anti-synapsin antibodies,...
10.
Tuma P, Nyasae L, Backer J, Hubbard A
J Cell Biol
. 2001 Sep;
154(6):1197-208.
PMID: 11564757
Using a microinjection approach to study apical plasma membrane protein trafficking in hepatic cells, we found that specific inhibition of Vps34p, a class III phosphoinositide 3 (PI-3) kinase, nearly perfectly...