A J Wolstenholme
Overview
Explore the profile of A J Wolstenholme including associated specialties, affiliations and a list of published articles.
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37
Citations
1030
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Recent Articles
1.
Williamson S, Wolstenholme A
J Helminthol
. 2011 Jul;
86(2):202-8.
PMID: 21729384
P-glycoproteins (P-gps) are proteins that function as efflux pumps, removing lipophilic xenobiotic compounds from cells. There is evidence that P-gps play a role in the resistance of parasitic nematodes to...
2.
von Samson-Himmelstjerna G, Walsh T, Donnan A, Carriere S, Jackson F, Skuce P, et al.
Parasitology
. 2009 Jan;
136(3):349-58.
PMID: 19154653
Benzimidazoles (BZ) are widely used to treat parasitic nematode infections of humans and animals, but resistance is widespread in veterinary parasites. Several polymorphisms in beta-tubulin genes have been associated with...
3.
McCavera S, Walsh T, Wolstenholme A
Parasitology
. 2007 Jul;
134(Pt 8):1111-21.
PMID: 17608971
SUMMARYLigand-gated chloride channels, including the glutamate-(GluCl) and GABA-gated channels, are the targets of the macrocyclic lactone (ML) family of anthelmintics. Changes in the sequence and expression of these channels can...
4.
Reaves B, Wolstenholme A
Biochem Soc Trans
. 2007 Jan;
35(Pt 1):77-80.
PMID: 17233605
TRP (transient receptor potential) cationic channels are key molecules that are involved in a variety of diverse biological processes ranging from fertility to osmosensation and nociception. Increasing our knowledge of...
5.
Wolstenholme A, Rogers A
Parasitology
. 2006 Mar;
131 Suppl:S85-95.
PMID: 16569295
The macrocyclic lactones are the biggest selling and arguably most effective anthelmintics currently available. They are good substrates for the P-glycoproteins, which might explain their selective toxicity for parasites over...
6.
Coles G, Rhodes A, Wolstenholme A
Vet Parasitol
. 2005 Apr;
129(3-4):345-7.
PMID: 15845291
Lambs infected with two isolates, one British and one American, of Haemonchus contortus were treated with increasing doses of ivermectin. Eggs from the highest dose that had not eliminated the...
7.
Coles G, Jackson F, Taylor M, Wolstenholme A
Vet Rec
. 2004 Oct;
155(9):253-4.
PMID: 15461361
No abstract available.
8.
Cheeseman C, Delany N, Woods D, Wolstenholme A
Mol Biochem Parasitol
. 2001 May;
114(2):161-8.
PMID: 11378196
Glutamate-gated chloride channels (GluCls) are targets for the avermectin anthelmintics. A family of five GluCl subunit genes encoding seven subunits has been identified in Caenorhabditis elegans. We have previously shown...
9.
Lind R, Hardick D, Blagbrough I, Potter B, Wolstenholme A, Davies A, et al.
Insect Biochem Mol Biol
. 2001 Mar;
31(6-7):533-42.
PMID: 11267892
Nicotinic acetylcholine receptors (nAChR) of insect and other invertebrates are heterogeneous and new tools are needed to dissect their multiplicity. [(3)H]-Methyllycaconitine ([(3)H]-MLA) is a novel radioligand which is a potent...
10.
Horoszok L, Raymond V, Sattelle D, Wolstenholme A
Br J Pharmacol
. 2001 Mar;
132(6):1247-54.
PMID: 11250875
1. We report the cloning and expression of a novel Caenorhabditis elegans polypeptide, GLC-3, with high sequence identity to previously cloned L-glutamate-gated chloride channel subunits from nematodes and insects. 2....