A J Macpherson
Overview
Explore the profile of A J Macpherson including associated specialties, affiliations and a list of published articles.
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Articles
45
Citations
2178
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0
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Recent Articles
1.
Brasseit J, Althaus-Steiner E, Faderl M, Dickgreber N, Saurer L, Genitsch V, et al.
Mucosal Immunol
. 2015 Sep;
9(3):689-701.
PMID: 26376366
Current therapies to treat inflammatory bowel diseases have limited efficacy, significant side effects, and often wane over time. Little is known about the cellular and molecular mechanisms operative in the...
2.
Macpherson A, McCoy K
Mucosal Immunol
. 2014 Dec;
8(3):476-86.
PMID: 25492472
An appreciation of the importance of interactions between microbes and multicellular organisms is currently driving research in biology and biomedicine. Many human diseases involve interactions between the host and the...
3.
Geuking M, McCoy K, Macpherson A
Semin Immunol
. 2011 Dec;
24(1):36-42.
PMID: 22138187
The large production of immunoglobulin (Ig)A is energetically costly. The fact that evolution retained this apparent luxury of intestinal class switch recombination to IgA within the human population strongly indicates...
4.
Macpherson A, McCoy K, Johansen F, Brandtzaeg P
Mucosal Immunol
. 2008 Dec;
1(1):11-22.
PMID: 19079156
The production of immunoglobulin A (IgA) in mammals exceeds all other isotypes, and it is mostly exported across mucous membranes. The discovery of IgA and the realization that it dominates...
5.
Macpherson A
Curr Top Microbiol Immunol
. 2006 Aug;
308:117-36.
PMID: 16922088
The lower intestine of mammals is colonised by a dense flora composed mainly of non-pathogenic commensal bacteria. These intestinal bacteria have a wide-ranging impact on host immunity and physiology. One...
6.
7.
King K, Moody A, Fisher S, Mirza M, Cuthbert A, Hampe J, et al.
Eur J Immunogenet
. 2003 Jun;
30(3):187-90.
PMID: 12786995
The immunoglobulin superfamily 6 gene (IGSF6) on chromosome 16p11-p12 has been investigated as a positional and functional candidate for inflammatory bowel disease (IBD) susceptibility. Screening of the six exons of...
8.
Macpherson A, Martinic M, Harris N
Cell Mol Life Sci
. 2003 Feb;
59(12):2088-96.
PMID: 12568335
There is an immense load of non-pathogenic commensal bacteria in the distal small intestine and the colon of mammals. The physical barrier that prevents penetration (translocation) of these organisms into...
9.
Bridger S, Lee J, Bjarnason I, Jones J, Macpherson A
Gut
. 2002 Jun;
51(1):21-5.
PMID: 12077086
Background And Aims: Smoking tobacco has opposite effects on the different forms of inflammatory bowel disease (IBD). It predisposes to the development of Crohn's disease (CD) yet is associated with...
10.
Macpherson A, Hunziker L, McCoy K, Lamarre A
Microbes Infect
. 2001 Oct;
3(12):1021-35.
PMID: 11580989
IgA is the most abundant immunoglobulin produced in mammals; most is secreted as a dimer across mucous membranes. This review discusses the different mechanisms of induction of IgA, and its...