A J Kaumann
Overview
Explore the profile of A J Kaumann including associated specialties, affiliations and a list of published articles.
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Articles
155
Citations
2525
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Recent Articles
1.
Galindo-Tovar A, Kaumann A
Br J Pharmacol
. 2007 Dec;
153(4):710-20.
PMID: 18084319
Background And Purpose: beta(1) and beta(2)-adrenoceptors coexist in murine heart but beta(2)-adrenoceptor-mediated effects have not been detected in atrial and ventricular tissues, possibly due to marked phosphodiesterase (PDE) activity. We...
2.
Molenaar P, Chen L, Semmler A, Parsonage W, Kaumann A
Clin Exp Pharmacol Physiol
. 2007 Aug;
34(10):1020-8.
PMID: 17714089
1. In atrium and ventricle from failing and non-failing human hearts, activation of beta(1)- or beta(2)-adrenoceptors causes increases in contractile force, hastening of relaxation, protein kinase A-catalysed phosphorylation of proteins...
3.
Neidhold S, Eichhorn B, Kasper M, Ravens U, Kaumann A
Br J Pharmacol
. 2006 Dec;
150(3):261-70.
PMID: 17179950
Background And Purpose: Adrenoceptors can associate with cardiac caveolae. To investigate the function of vascular caveolae, adrenoceptor-mediated effects were compared in the saphenous artery of caveolin-1 knockout (cav-1KO) and wild-type...
4.
Christ T, Engel A, Ravens U, Kaumann A
Naunyn Schmiedebergs Arch Pharmacol
. 2006 Nov;
374(3):249-53.
PMID: 17106669
Activation of both beta(1)- and beta(2)-adrenoceptors increases the contractility of human atrial myocardium through cyclic AMP-dependent pathways. Cyclic AMP is hydrolised by phosphodiesterases, but little is known about which isoenzymes...
5.
Joseph S, Lynham J, Grace A, Colledge W, Kaumann A
Br J Pharmacol
. 2004 Mar;
142(1):51-6.
PMID: 15037517
1. Substitution of arginine by glycine at position 389, a frequent beta(1)-adrenoceptor polymorphism, reduces adenylyl cyclase stimulation by (-)-isoprenaline. beta(1)-Adrenoceptors mediate the effects of catecholamines and nonconventional partial agonists ((-)-CGP12177)...
6.
Bach T, Syversveen T, Kvingedal A, Krobert K, Brattelid T, Kaumann A, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 2001 Feb;
363(2):146-60.
PMID: 11218067
5-Hydroxytryptamine (5-HT) increases human heart rate and atrial contractile force and hastens atrial relaxation through 5-HT4 receptors. Moreover, 5-HT may be arrhythmogenic and give rise to atrial fibrillation. It is...
7.
Kaumann A, Engelhardt S, Hein L, Molenaar P, Lohse M
Naunyn Schmiedebergs Arch Pharmacol
. 2001 Feb;
363(1):87-93.
PMID: 11191841
Some beta1- and beta2-adrenoceptor-blocking agents, such as (-)-CGP 12177, cause cardiostimulant effects at concentrations considerably higher than those that antagonise the effects of catecholamines. The cardiostimulant effects of these non-conventional...
8.
Oostendorp J, Preitner F, Moffatt J, Jimenez M, Giacobino J, Molenaar P, et al.
Br J Pharmacol
. 2000 Jun;
130(4):747-58.
PMID: 10864880
The smooth muscle relaxant responses to the mixed beta(3)-, putative beta(4)-adrenoceptor agonist, (-)-CGP 12177 in rat colon are partially resistant to blockade by the beta(3)-adrenoceptor antagonist SR59230A suggesting involvement of...
9.
Oostendorp J, Kaumann A
Naunyn Schmiedebergs Arch Pharmacol
. 2000 Feb;
361(2):134-45.
PMID: 10685868
Activation of beta1-, beta2-, beta 3- and putative beta4-adrenoceptors modifies cardiac function. These receptors are usually coupled to Gs protein, but beta2- and beta3-adrenoceptors could also couple to Gi/o proteins....
10.
Burrell K, Molenaar P, Dawson P, Kaumann A
J Pharmacol Exp Ther
. 1999 Dec;
292(1):449-59.
PMID: 10604982
It is known that binding sites with endothelin(A) (ET)(A) and ET(B) receptor characteristics coexist in human heart but little is known about the receptors that mediate cardiostimulant effects of ET...