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A J Ingram

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Articles 60
Citations 330
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Recent Articles
1.
Guan T, Chen G, Gao B, Janssen M, Uttarwar L, Ingram A, et al.
Diabetologia . 2013 Jun; 56(9):2068-77. PMID: 23793581
Aims/hypothesis: Glomerular matrix protein accumulation, mediated largely by resident mesangial cells (MCs), is central to the pathogenesis of diabetic nephropathy. We previously showed that caveolin (CAV)-1/caveolae mediate matrix upregulation by...
2.
Zhang Y, Peng F, Gao B, Ingram A, Krepinsky J
Am J Physiol Renal Physiol . 2011 Oct; 302(1):F159-72. PMID: 21975875
Glomerular matrix accumulation is a hallmark of diabetic nephropathy. We previously showed that RhoA activation by high glucose in mesangial cells (MC) leads to matrix upregulation (Peng F, Wu D,...
3.
Uttarwar L, Peng F, Wu D, Kumar S, Gao B, Ingram A, et al.
Am J Physiol Renal Physiol . 2011 Feb; 300(4):F921-31. PMID: 21289053
Glomerular matrix accumulation is a hallmark of diabetic nephropathy. We showed that transactivation of the epidermal growth factor receptor (EGFR) is an important mediator of matrix upregulation in mesangial cells...
4.
Wu D, Peng F, Zhang B, Ingram A, Kelly D, Gilbert R, et al.
Am J Physiol Renal Physiol . 2009 Jul; 297(3):F822-34. PMID: 19605547
Glomerular matrix accumulation is a hallmark of diabetic nephropathy. We have recently shown that epidermal growth factor receptor (EGFR) transactivation mediates high glucose (HG)-induced collagen I upregulation through PI3K-PKCbeta1-Akt signaling...
5.
Wu D, Peng F, Zhang B, Ingram A, Gao B, Krepinsky J
Diabetologia . 2007 Jul; 50(9):2008-2018. PMID: 17622510
Aims/hypothesis: Glomerular matrix accumulation is a hallmark of diabetic nephropathy. Recent data have linked the serine/threonine kinase protein kinase B (Akt) to matrix modulation. Here, we studied its role in...
6.
Shastry S, Ingram A, Scholey J, James L
Kidney Int . 2006 Dec; 71(4):304-11. PMID: 17149372
Hyperhomocysteinemia is prevalent among patients with chronic kidney disease (CKD) and has been linked to progressive kidney and vascular diseases. Increased glomerular mesangial cell (MC) turnover, including proliferation and apoptosis,...
7.
Brimble K, Rabbat C, Treleaven D, Ingram A
Clin Nephrol . 2002 Sep; 58(2):122-7. PMID: 12227684
Aim: The purpose of this study was to evaluate the clinical utility of Doppler ultrasound (US) prior to native forearm arteriovenous fistula (AVF) creation. Materials And Methods: US mapping was...
8.
Brimble K, Rabbat C, Schiff D, Ingram A
Semin Dial . 2001 Oct; 14(5):314-7. PMID: 11679094
Arteriovenous fistula (AVF) is the preferred access for long-term hemodialysis, with superior long-term patency rates; however, early failure rates are significant. Recent evidence has brought into question the preferred site...
9.
Tang D, Okada H, Ruland J, Liu L, Stambolic V, Mak T, et al.
J Biol Chem . 2001 Jun; 276(32):30461-6. PMID: 11399756
Akt is a serine-threonine kinase known to exert antiapoptotic effects through several downstream targets. Akt is cleaved during mitochondrial-mediated apoptosis in a caspase-dependent manner. The reason for this is not...
10.
Clase C, Crowther M, Ingram A, Cina C
J Thromb Thrombolysis . 2001 Jun; 11(2):127-36. PMID: 11406727
Urokinase, previously used to restore patency to thrombosed haemodialysis catheters, is now unavailable in North America. We performed systematic reviews of four questions related to the safety and efficacy of...