A J Hutt
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Explore the profile of A J Hutt including associated specialties, affiliations and a list of published articles.
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53
Citations
438
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Recent Articles
1.
Cizmarikova R, Valentova J, Hutt A, Sedlakova S
Ceska Slov Farm
. 2005 Oct;
54(5):201-6.
PMID: 16209433
Besides chromatographic methods and biocatalyzed reactions, another alternative method of obtaining enantiomeric forms of beta-blockers is stereoselective synthesis. This paper links up with two preceding surveys concerning beta-blockers--groups of chiral...
2.
Valentova J, Hutt A
Ceska Slov Farm
. 2005 Jan;
53(6):285-93.
PMID: 15630994
Chirality of drugs, particularly the comparison of efficacy of enantiomers and their racemic mixtures, has become an object of serious interest of pharmaceutical researchers in recent ten or fifteen years....
3.
Patel B, Jackson S, Swift C, Hutt A
Xenobiotica
. 2003 Oct;
33(10):1043-57.
PMID: 14555340
1. The stereoselective metabolism and pharmacokinetics of the enantiomers of flurbiprofen were investigated following the oral administration of the racemic drug (100 mg) to four young and four elderly healthy...
4.
Tan S, Patel B, Jackson S, Swift C, Hutt A
Xenobiotica
. 2002 Sep;
32(8):683-97.
PMID: 12296989
1. The stereoselective metabolism and pharmacokinetics of the enantiomers of ibuprofen have been investigated following the oral administration of the racemic drug (400 mg) to 12 healthy volunteers.2. The stereochemical...
5.
Fallon J, Shah D, Kicman A, Hutt A, Henry J, Cowan D, et al.
Ann N Y Acad Sci
. 2002 Jul;
965:399-409.
PMID: 12105115
3,4-Methylenedioxymethamphetamine (MDMA) has been reported to cause hyponatraemia, which appears to result from inappropriate secretion of the antidiuretic hormone arginine vasopressin (AVP). After administration of a low dose of (R,S)-MDMA...
6.
Forsling M, Fallon J, Kicman A, Hutt A, Cowan D, Henry J
J Pharm Pharmacol
. 2001 Nov;
53(10):1357-63.
PMID: 11697543
The aim of this investigation was to examine the effect of 3,4-methylenedioxymethamphetamine (MDMA) administration on arginine vasopressin (AVP) release. (R,S)-MDMA (40 mg) was administered to eight normally hydrated healthy male...
7.
Nnane L, Damani L, Hutt A
Eur J Drug Metab Pharmacokinet
. 2001 Sep;
26(1-2):17-24.
PMID: 11554429
Ethyl methyl sulphide (EMS) is a simple dialkyl sulphide, which occurs naturally and forms part structures of more complex drug molecules. EMS is oxidized to the corresponding sulphoxide (EMSO) and...
8.
Begent L, Hill A, Steventon G, Hutt A, Pallister C, Cowell D
J Pharm Pharmacol
. 2001 May;
53(4):481-6.
PMID: 11341364
The enzyme vitamin K1 2,3 epoxide reductase is responsible for converting vitamin K1 2,3 epoxide to vitamin K1 quinone thus completing the vitamin K cycle. The enzyme is also the...
9.
Hollinshead C, Hanna M, Barlow D, De Biasi V, Bucknall D, Camilleri P, et al.
Biochim Biophys Acta
. 2001 Mar;
1511(1):49-59.
PMID: 11248204
Neutron specular reflection has been used to study the structure of a monolayer of dimyristoylphosphatidylcholine (DMPC) deposited using the Langmuir-Blodgett technique onto a silicon oxide substrate. A self-assembled monolayer of...
10.
Hadley M, Camilleri P, Hutt A
Electrophoresis
. 2000 Jul;
21(10):1953-76.
PMID: 10879955
Enantiospecific analysis has an important role in drug metabolism and pharmacokinetic investigations and its now no longer acceptable to determine total drug, or metabolite, concentrations following the administration of a...