A J Giaccia
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Explore the profile of A J Giaccia including associated specialties, affiliations and a list of published articles.
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81
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4367
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Recent Articles
1.
Zhou L, Liu X, Sun M, Zhang X, German P, Bai S, et al.
Oncogene
. 2015 Sep;
35(21):2687-97.
PMID: 26364599
Antiangiogenic therapy resistance occurs frequently in patients with metastatic renal cell carcinoma (RCC). The purpose of this study was to understand the mechanism of resistance to sunitinib, an antiangiogenic small...
2.
Finger E, Cheng C, Williams T, Rankin E, Bedogni B, Tachiki L, et al.
Oncogene
. 2013 Feb;
33(9):1093-100.
PMID: 23435419
Metastatic melanoma remains a devastating disease with a 5-year survival rate of less than five percent. Despite recent advances in targeted therapies for melanoma, only a small percentage of melanoma...
3.
Fox M, Lemmon M, Giaccia A, Minton N, Brown J
Methods Mol Med
. 2011 Mar;
35:413-8.
PMID: 21390820
Many murine and human tumors contain hypoxic or necrotic regions in which the oxygen tension is abnormally low. For example,>50% of primary tumors of the breast, cervix, and head and...
4.
Chan D, Giaccia A
Br J Cancer
. 2010 May;
103(1):1-5.
PMID: 20461086
Originally identified as the enzymes responsible for catalysing the oxidation of specific, conserved proline residues within hypoxia-inducible factor-1alpha (HIF-1alpha), the additional roles for the prolyl hydroxylase domain (PHD) proteins have...
5.
Rankin E, Giaccia A
Cell Death Differ
. 2008 Feb;
15(4):678-85.
PMID: 18259193
Hypoxia-inducible factors (HIFs) are essential mediators of the cellular oxygen-signaling pathway. They are heterodimeric transcription factors consisting of an oxygen-sensitive alpha subunit (HIF-alpha) and a constitutive beta subunit (HIF-beta) that...
6.
Soltys S, Le Q, Shi G, Tibshirani R, Giaccia A, Koong A
Clin Cancer Res
. 2004 Jul;
10(14):4806-12.
PMID: 15269156
Purpose: Our study was undertaken to determine the utility of plasma proteomic profiling using surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry for the detection of head and neck squamous cell...
7.
Liu S, Minton N, Giaccia A, Brown J
Gene Ther
. 2002 Mar;
9(4):291-6.
PMID: 11896468
A major obstacle in cancer gene therapy is selective tumor delivery. Previous studies have suggested that genetically engineered anaerobes of the genus Clostridium might be gene therapy vectors because of...
8.
Alarcon R, Denko N, Giaccia A
Novartis Found Symp
. 2001 Dec;
240:115-28; discussion 128-32.
PMID: 11727925
The p53 tumour suppressor gene is capable of activating both death receptor and mitochondrial-signalled forms of apoptotic cell death in response to diverse stimuli. Studies have suggested that impairment of...
9.
Popovici R, Lu M, Bhatia S, Faessen G, Giaccia A, Giudice L
J Clin Endocrinol Metab
. 2001 Jun;
86(6):2653-9.
PMID: 11397868
Intrauterine growth restriction (IUGR) can be a consequence of decreased uterine blood flow (uteroplacental insufficiency) and maternal and fetal hypoxia. Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are...
10.
Chen E, Mazure N, Cooper J, Giaccia A
Cancer Res
. 2001 Apr;
61(6):2429-33.
PMID: 11289110
Hypoxia initiates numerous intracellular signaling pathways important in regulating cell proliferation, differentiation, and death. In this study, we investigated the pathway that hypoxia uses to activate Akt and inactivate glycogen...