A Ian Cassady
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Explore the profile of A Ian Cassady including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
180
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Recent Articles
1.
Chandler-Temple A, Kingshott P, Wentrup-Byrne E, Cassady A, Grondahl L
J Biomed Mater Res A
. 2012 Sep;
101(4):1047-58.
PMID: 22965526
A series of surface-modified expanded poly(tetrafluoroethylene) membranes showed varied levels of in vitro macrophage proinflammatory response. Membranes containing a mixture of phosphate and hydroxyl groups (as determined by X-ray photoelectron...
2.
Gradin P, Hollberg K, Cassady A, Lang P, Andersson G
Cells Tissues Organs
. 2012 Jan;
196(1):68-81.
PMID: 22248481
Bone remodeling is a central event in the maintenance of skeletal tissue, and involves cycles of resorption followed by the formation of bone tissue. The activity of osteoclasts and osteoblasts...
3.
Endo-Munoz L, Cumming A, Rickwood D, Wilson D, Cueva C, Ng C, et al.
Cancer Res
. 2010 Sep;
70(18):7063-72.
PMID: 20823153
We conducted a transcriptomic screen of osteosarcoma (OS) biopsies and found that expression of osteoclast-specific tartrate-resistant acid phosphatase 5 (ACP5/TRAP) is significantly downregulated in OS compared with nonmalignant bone (P...
4.
Way K, Dinh H, Keene M, White K, Clanchy F, Lusby P, et al.
J Leukoc Biol
. 2009 Feb;
85(5):766-78.
PMID: 19181863
Information about the development and function of human macrophage lineage populations, such as osteoclasts, is limited because of the lack of defined in vitro systems for their large-scale generation. Two...
5.
Hadler K, Huber T, Cassady A, Weber J, Robinson J, Burrows A, et al.
BMC Res Notes
. 2008 Sep;
1:78.
PMID: 18771593
Background: Tartrate-resistant acid phosphatases (TRAcPs), also known as purple acid phosphatases (PAPs), are a family of binuclear metallohydrolases that have been identified in plants, animals and fungi. The human enzyme...
6.
Lang P, van Harmelen V, Ryden M, Kaaman M, Parini P, Carneheim C, et al.
PLoS One
. 2008 Mar;
3(3):e1713.
PMID: 18320034
Background: Obesity is associated with macrophage infiltration of adipose tissue, which may link adipose inflammation to insulin resistance. However, the impact of inflammatory cells in the pathophysiology of obesity remains...
7.
Sharma S, Hu R, Bronisz A, Meadows N, Lusby T, Fletcher B, et al.
Crit Rev Eukaryot Gene Expr
. 2006 Nov;
16(3):253-77.
PMID: 17073554
The regulation of osteoclast differentiation in the bone microenvironment is critical for normal bone remodeling, as well as for various human bone diseases. Over the last decade, our knowledge of...
8.
Yip K, Zheng M, Steer J, Giardina T, Han R, Lo S, et al.
J Bone Miner Res
. 2005 Jul;
20(8):1462-71.
PMID: 16007343
Unlabelled: The mechanism by which TG modulates osteoclast formation and apoptosis is not clear. In this study, we showed a biphasic effect of TG on osteoclast formation and apoptosis through...
9.
Mitic N, Valizadeh M, Leung E, de Jersey J, Hamilton S, Hume D, et al.
Arch Biochem Biophys
. 2005 Jun;
439(2):154-64.
PMID: 15950921
Proteolytic cleavage in an exposed loop of human tartrate-resistant acid phosphatase (TRAcP) with trypsin leads to a significant increase in activity. At each pH value between 3.25 and 8.0 the...
10.
Raisanen S, Alatalo S, Ylipahkala H, Halleen J, Cassady A, Hume D, et al.
Biochem Biophys Res Commun
. 2005 Apr;
331(1):120-6.
PMID: 15845367
Activated macrophages and osteoclasts express high amounts of tartrate-resistant acid phosphatase (TRACP, acp5). TRACP has a binuclear iron center with a redox-active iron that has been shown to catalyze the...