A Hewer
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Explore the profile of A Hewer including associated specialties, affiliations and a list of published articles.
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Articles
108
Citations
926
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Recent Articles
1.
Cooper C, Ribeiro O, Hewer A, Walsh C, Pal K, Grover P, et al.
Carcinogenesis
. 2012 Jan;
1(3):233-43.
PMID: 22283004
The principal nucleoside-hydrocarbon adducts present in hydrolysates of DNA that had been isolated either from mouse skin or from hamster embryo cells treated with benz[a]anthracene have been examined by chromatography...
2.
Al-Buheissi S, Cole K, Hewer A, Kumar V, Bryan R, Hudson D, et al.
Prostate
. 2006 Feb;
66(8):876-85.
PMID: 16496416
Background: Dietary heterocyclic amines (HCAs) are carcinogenic in rodent prostate requiring activation by enzymes such as cytochrome P450 (CYP) and N-acetyltransferase (NAT). Methods: We investigated by Western blotting and immunohistochemistry...
3.
4.
Donnelly E, Bardwell H, Thomas G, Williams E, Hoper M, Crowe P, et al.
Br J Cancer
. 2005 Jun;
92(12):2160-5.
PMID: 15928667
Metallothionein (MT) crypt-restricted immunopositivity indices (MTCRII) are colonic crypt stem cell mutation markers that may be induced early and in abundance after mutagen treatment. Metallothionein is the endogenous reporter gene...
5.
Berge G, Ovrebo S, Botnen I, Hewer A, Phillips D, Haugen A, et al.
Br J Cancer
. 2004 May;
91(2):333-8.
PMID: 15162144
Resveratrol (trans-3,4',5-trihydroxystilbene), a phytoalexin present in various plants and foods, has in several in vitro and in vivo studies demonstrated cancer chemopreventive and chemotherapeutic potential. We investigated the in vitro...
6.
Telli-Karakoc F, Ruddock P, Bird D, Hewer A, van Schanke A, Phillips D, et al.
Mar Environ Res
. 2002 Nov;
54(3-5):511-5.
PMID: 12408610
Juvenile turbot (Scophthalmus maximus) were injected intraperitoneally with either corn oil or 5 mg/kg benzo[a]pyrene (BaP) dissolved in corn oil and sampled I and 3 days after injection. After 1...
7.
Peters L, Telli-Karakoc F, Hewer A, Phillips D
Mar Environ Res
. 2002 Nov;
54(3-5):499-503.
PMID: 12408608
Turbot (Scophthalmus maximus) and mussel (Mytilus edulis) microsomes were incubated with DNA to examine if microsomal in vitro metabolism of BaP could result in DNA adducts detected by 32P-postlabelling. Turbot...
8.
Wallace M, Forbes A, Beveridge I, Spigelman A, Hewer A, Venitt S, et al.
Dis Colon Rectum
. 2001 Nov;
44(11):1585-9.
PMID: 11711728
Purpose: Bile has been implicated in the pathogenesis of duodenal polyps in patients with familial adenomatous polyposis. In vitro experiments have shown that familial adenomatous polyposis bile is capable of...
9.
Hussain S, Amstad P, Raja K, Sawyer M, Hofseth L, Shields P, et al.
Cancer Res
. 2001 Aug;
61(17):6350-5.
PMID: 11522624
p53 mutations are common in lung cancer. In smoking-associated lung cancer,the occurrence of G:C to T:A transversions at hotspot codons, e.g., 157, 248, 249,and 273, has been linked to the...
10.
Osborne M, Hewer A, Phillips D
Chem Res Toxicol
. 2001 Jul;
14(7):888-93.
PMID: 11453736
The genotoxic tamoxifen metabolite alpha-hydroxytamoxifen has been resolved into R- and S-enantiomers. This was achieved by preparing its ester with S-camphanic acid, chromatographic separation into two diastereoisomers, and hydrolysis to...