A G Harpur
Overview
Explore the profile of A G Harpur including associated specialties, affiliations and a list of published articles.
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21
Citations
1221
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Recent Articles
1.
Harpur A, Wouters F, Bastiaens P
Nat Biotechnol
. 2001 Feb;
19(2):167-9.
PMID: 11175733
Fluorescence resonance energy transfer (FRET) detection in fusion constructs consisting of green fluorescent protein (GFP) variants linked by a sequence that changes conformation upon modification by enzymes or binding of...
2.
Chang C, Dietrich J, Harpur A, Lindquist J, Haude A, Loke Y, et al.
J Immunol
. 1999 Oct;
163(9):4651-4.
PMID: 10528161
Transmembrane adapter proteins are a class of molecules that mediate signals from an extracellular receptor to the cytoplasm of the cell. We have cloned a novel transmembrane adapter protein called...
3.
Harpur A, Layton M, Das P, Bottomley M, Panayotou G, Driscoll P, et al.
J Biol Chem
. 1999 Apr;
274(18):12323-32.
PMID: 10212202
The regulatory subunit of phosphatidylinositol 3-kinase, p85, contains a number of well defined domains involved in protein-protein interactions, including an SH3 domain and two SH2 domains. In order to investigate...
4.
Layton M, Harpur A, Panayotou G, Bastiaens P, Waterfield M
J Biol Chem
. 1998 Dec;
273(50):33379-85.
PMID: 9837914
Phosphatidylinositol 3-kinase (PI3K) is a heterodimeric enzyme comprising a p110 catalytic subunit and a p85 regulatory subunit. We have recently shown that the isolated p85 subunit exists as a dimer;...
5.
Lackmann M, Harpur A, Oates A, Mann R, Gabriel A, Meutermans W, et al.
Growth Factors
. 1998 Oct;
16(1):39-51.
PMID: 9777369
The basic framework for the JAK/STAT pathway is well documented. Recruitment of latent cytoplasmic STAT transcription factors to tyrosine phosphorylated docking sites on cytokine receptors and their JAK-mediated phosphorylation instigates...
6.
Briscoe J, ROGERS N, Witthuhn B, Watling D, Harpur A, Wilks A, et al.
EMBO J
. 1996 Feb;
15(4):799-809.
PMID: 8631301
The receptor-associated protein tyrosine kinases JAK1 and JAK2 are both required for the interferon (IFN)-gamma response. The effects of expressing kinase-negative JAK mutant proteins on signal transduction in response to...
7.
Novak U, Harpur A, Paradiso L, Kanagasundaram V, Jaworowski A, Wilks A, et al.
Blood
. 1995 Oct;
86(8):2948-56.
PMID: 7579387
Colony-stimulating factor 1 (CSF-1) causes the activation of STAT1 and STAT3 transcription factors in bone marrow macrophages (BMM), in the macrophage cell line BAC1.2F5, and in fibroblasts that express the...
8.
Eilers A, Georgellis D, Klose B, Schindler C, Ziemiecki A, Harpur A, et al.
Mol Cell Biol
. 1995 Jul;
15(7):3579-86.
PMID: 7791765
Gamma interferon (IFN-gamma), a macrophage-activating cytokine, modulates gene expression through the activity of a transcription factor designated IFN-gamma activation factor (GAF). GAF is formed after phosphorylation on tyrosine and dimerization...
9.
Ziemiecki A, Harpur A, Wilks A
Trends Cell Biol
. 1994 Jun;
4(6):207-12.
PMID: 14731679
Protein tyrosine kinases (PTKs) are integral components of the cellular machinery that mediates the transduction and/or processing of many extra- and intracellular signals. Members of the JAK family of intracellular...
10.
Dusanter-Fourt I, Muller O, Ziemiecki A, Mayeux P, Drucker B, Djiane J, et al.
EMBO J
. 1994 Jun;
13(11):2583-91.
PMID: 8013458
The mechanism of action of prolactin (PRL) was studied in murine lymphoid BAF-3 cells transfected with either the long form of the PRL receptor (PRL-R), or a chimeric receptor consisting...