A F James
Overview
Explore the profile of A F James including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
27
Citations
286
Followers
0
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Recent Articles
1.
Zakkar M, Ascione R, James A, Angelini G, Suleiman M
Pharmacol Ther
. 2015 Jun;
154:13-20.
PMID: 26116810
Postoperative atrial fibrillation (POAF) is a common complication of cardiac surgery that occurs in up to 60% of patients. POAF is associated with increased risk of cardiovascular mortality, stroke and...
2.
Orchard C, Bryant S, James A
J Physiol
. 2013 May;
591(17):4141-7.
PMID: 23652596
The transverse (t-) tubules of mammalian ventricular myocytes are invaginations of the surface membrane. The function of many of the key proteins involved in excitation-contraction coupling is located predominantly at...
3.
Brown R, James A, Pitchford J, Plank M
J Theor Biol
. 2012 Jul;
310:231-8.
PMID: 22789620
Understanding the persistence and growth of natural populations in environments subject to random localised change is relevant both to the conservation of threatened species and to the control of invasive...
4.
Baylie R, Cheng H, Langton P, James A
J Physiol Pharmacol
. 2010 Nov;
61(5):543-50.
PMID: 21081797
(-)-Menthol and icilin are agonists of the thermoreceptor non-selective cation channel, TRPM8, and are commonly used to investigate TRPM8 function without a full appreciation of their non-specific effects. To investigate...
5.
Ridley J, Shuba Y, James A, Hancox J
J Physiol Pharmacol
. 2008 Oct;
59(3):395-407.
PMID: 18953086
hERG (human ether-a-go-go-related gene) potassium (K+) channels are expressed in a range of tissue types including neuroblastoma cells and the heart, in which hERG K+ current is important for action...
6.
James A, Hancox J
Br J Pharmacol
. 2007 Sep;
152(7):981-3.
PMID: 17828293
The common cardiac arrhythmia atrial fibrillation (AF) tends to show progression in its severity, which is associated with 'remodelling': structural and electrophysiological changes that facilitate arrhythmia induction and maintenance. In...
7.
James A
Br J Pharmacol
. 2007 Aug;
152(4):417-9.
PMID: 17721550
Endothelin-1 (ET-1) is a peptide hormone produced within the myocardium which may modulate myocardial contractility in a paracrine-autocrine fashion. In the majority of species, ET-1 has a direct positive inotropic...
8.
Duncan R, McPate M, Ridley J, Gao Z, James A, Leishman D, et al.
Biochem Pharmacol
. 2007 Jun;
74(3):425-37.
PMID: 17560554
HERG (human ether-à-go-go-related gene) encodes channels responsible for the cardiac rapid delayed rectifier potassium current, I(Kr). This study investigated the effects on HERG channels of doxepin, a tricyclic antidepressant linked...
9.
Cheng H, James A, Foster R, Hancox J, Bates D
Arterioscler Thromb Vasc Biol
. 2006 Jun;
26(8):1768-76.
PMID: 16763162
Objective: Vascular endothelial growth factor (VEGF) exerts many of its effects by stimulating endothelial calcium influx, but little is known about channels mediating VEGF-induced cation entry. The aim of this...
10.
Zhang Y, James A, Hancox J
Cell Calcium
. 2001 Dec;
30(5):351-60.
PMID: 11733942
The cardiac Na+-Ca2+ exchanger participates in Ca homeostasis, and Na+-Ca2+ exchanger-mediated ionic current (I(NaCa)) also contributes to the regulation of cardiac action potential duration. Moreover, I(NaCa) can contribute to arrhythmogenesis...