A E Granovsky
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Explore the profile of A E Granovsky including associated specialties, affiliations and a list of published articles.
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12
Citations
124
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Recent Articles
1.
A conformational switch in the inhibitory gamma-subunit of PDE6 upon enzyme activation by transducin
Granovsky A, Artemyev N
Biochemistry
. 2001 Oct;
40(44):13209-15.
PMID: 11683629
In response to light, a photoreceptor G protein, transducin, activates cGMP-phosphodiesterase (PDE6) by displacing the inhibitory gamma-subunits (Pgamma) from the enzyme's catalytic sites. Evidence suggests that the activation of PDE6...
2.
Granovsky A, Artemyev N
J Biol Chem
. 2001 Apr;
276(24):21698-703.
PMID: 11285263
Photoreceptor cGMP phosphodiesterases (PDE6) are uniquely qualified to serve as effector enzymes in the vertebrate visual transduction cascade. In the dark-adapted photoreceptors, the activity of PDE6 is blocked via tight...
3.
Granovsky A, Artemyev N
J Biol Chem
. 2000 Oct;
275(52):41258-62.
PMID: 11024033
Photoreceptor cGMP phosphodiesterase (PDE6) is the effector enzyme in the G protein-mediated visual transduction cascade. In the dark, the activity of PDE6 is shut off by the inhibitory gamma subunit...
4.
Shevelev A, Aleoshin V, Trachuk L, Granovsky A, Kogan Y, Rumer L, et al.
Plasmid
. 2000 Apr;
43(3):190-9.
PMID: 10783297
The pLF1311 natural plasmid from Lactobacillus fermentum 1311 was used to construct a single-replicon vector suitable for rapid cloning in a wide range of gram-positive hosts and Escherichia coli. The...
5.
Granovsky A, Muradov K, Artemyev N
Methods Enzymol
. 2000 Mar;
315:635-46.
PMID: 10736731
No abstract available.
6.
Natochin M, Granovsky A, Muradov K, Artemyev N
J Biol Chem
. 1999 Mar;
274(12):7865-9.
PMID: 10075679
The visual GTP-binding protein, transducin, couples light-activated rhodopsin (R*) with the effector enzyme, cGMP phosphodiesterase in vertebrate photoreceptor cells. The region corresponding to the alpha4-helix and alpha4-beta6 loop of the...
7.
DAmours M, Granovsky A, Artemyev N, Cote R
Mol Pharmacol
. 1999 Mar;
55(3):508-14.
PMID: 10051534
The ability of inhibitors selective for the type 5 phosphodiesterase isozyme (PDE5) to act on the photoreceptor PDE isozyme (PDE6, the central effector enzyme for visual transduction) is poorly understood....
8.
Granovsky A, Natochin M, McEntaffer R, Haik T, Francis S, Corbin J, et al.
J Biol Chem
. 1998 Sep;
273(38):24485-90.
PMID: 9733741
Chimeric cGMP phosphodiesterases (PDEs) have been constructed using components of the cGMP-binding PDE (PDE5) and cone photoreceptor phosphodiesterase (PDE6alpha') in order to study structure and function of the photoreceptor enzyme....
9.
Natochin M, Granovsky A, Artemyev N
J Biol Chem
. 1998 Aug;
273(34):21808-15.
PMID: 9705319
Transducin is a photoreceptor-specific heterotrimeric GTP-binding protein that plays a key role in the vertebrate visual transduction cascade. Here, using scanning site-directed mutagenesis of the chimeric Galphat/Galphai1 alpha-subunit (Galphat/i), we...
10.
Granovsky A, McEntaffer R, Artemyev N
Cell Biochem Biophys
. 1998 Mar;
28(2-3):115-33.
PMID: 9515163
In the dark, the activity of the rod cGMP phosphodiesterase (PDE) catalytic alpha- and beta-subunits (P alpha beta) is inhibited by two gamma-subunits (P gamma). On light stimulation of the...