A David Woolfson
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Explore the profile of A David Woolfson including associated specialties, affiliations and a list of published articles.
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85
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2059
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Recent Articles
11.
Donnelly R, Mooney K, McCrudden M, Vicente-Perez E, Belaid L, Gonzalez-Vazquez P, et al.
J Pharm Sci
. 2014 Mar;
103(5):1478-86.
PMID: 24633895
We describe, for the first time, quantification of in-skin swelling and fluid uptake by hydrogel-forming microneedle (MN) arrays and skin barrier recovery in human volunteers. Such MN arrays, prepared from...
12.
Forbes C, McCoy C, Murphy D, Woolfson A, Moore J, Evans A, et al.
J Pharm Sci
. 2014 Mar;
103(5):1422-32.
PMID: 24585370
We previously reported nonaqueous silicone elastomer gels (SEGs) for sustained vaginal administration of the CCR5-targeted entry inhibitor maraviroc (MVC). Here, we describe chemically modified SEGs (h-SEGs) in which the hydrophobic...
13.
McCrudden M, Zaid Alkilani A, McCrudden C, McAlister E, McCarthy H, Woolfson A, et al.
J Control Release
. 2014 Feb;
180:71-80.
PMID: 24556420
We describe formulation and evaluation of novel dissolving polymeric microneedle (MN) arrays for the facilitated delivery of low molecular weight, high dose drugs. Ibuprofen sodium was used as the model...
14.
Donnelly R, Moffatt K, Zaid Alkilani A, Vicente-Perez E, Barry J, McCrudden M, et al.
Pharm Res
. 2014 Feb;
31(8):1989-99.
PMID: 24549822
Purpose: To investigate, for the first time, the influence of pharmacist intervention and the use of a patient information leaflet on self-application of hydrogel-forming microneedle arrays by human volunteers without...
15.
Donnelly R, Morrow D, McCrudden M, Zaid Alkilani A, Vicente-Perez E, OMahony C, et al.
Photochem Photobiol
. 2013 Nov;
90(3):641-7.
PMID: 24215482
We present "one-step application" dissolving and hydrogel-forming microneedle arrays (MN) for enhanced delivery of photosensitizers/precursors. MN (280 μm) prepared from 20% w/w poly(methylvinylether/maelic acid) and cross-linked with glycerol by esterification...
16.
Donnelly R, Raghu Raj Singh T, Zaid Alkilani A, McCrudden M, ONeill S, OMahony C, et al.
Int J Pharm
. 2013 May;
451(1-2):76-91.
PMID: 23644043
We describe, for the first time, the microbial characterisation of hydrogel-forming polymeric microneedle arrays and the potential for passage of microorganisms into skin following microneedle penetration. Uniquely, we also present...
17.
Donnelly R, Raghu Raj Singh T, Garland M, Migalska K, Majithiya R, McCrudden C, et al.
Adv Funct Mater
. 2013 Apr;
22(23):4879-4890.
PMID: 23606824
Unique microneedle arrays prepared from crosslinked polymers, which contain no drug themselves, are described. They rapidly take up skin interstitial fluid upon skin insertion to form continuous, unblockable, hydrogel conduits...
18.
Donnelly R, McCarron P, Morrow D, Woolfson A
Drug Dev Ind Pharm
. 2012 Nov;
39(11):1818-31.
PMID: 23167263
No bioadhesive patch-based system is currently marketed. This is despite an extensive number of literature reports on such systems detailing their advantages over conventional pressure sensitive adhesive-based patches in wet...
19.
Fetherston S, Malcolm R, Woolfson A
Ther Deliv
. 2012 Jul;
1(6):785-802.
PMID: 22834014
Background: Over half of all HIV-infected adults are women and heterosexual intercourse is a significant mode of viral transmission. This review examines the potential for using polymeric vaginal ring systems...
20.
Garland M, Migalska K, Tuan-Mahmood T, Raghu Raj Singh T, Majithija R, Caffarel-Salvador E, et al.
Int J Pharm
. 2012 Jun;
434(1-2):80-9.
PMID: 22669101
A plethora of studies have described the in vitro assessment of dissolving microneedle (MN) arrays for enhanced transdermal drug delivery, utilising a wide variety of model membranes as a representation...