A D Michel
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Explore the profile of A D Michel including associated specialties, affiliations and a list of published articles.
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85
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1251
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Recent Articles
1.
Sharif N, Nunes J, Michel A, Whiting R
Neurochem Int
. 2010 May;
15(3):325-32.
PMID: 20504502
The biochemical and pharmacological characteristics of sodium-dependent [(3)H]GBR12935 ([(3)H]GBR) binding to homogenates of rat, mouse, guinea-pig and dog striatum were determined at 23 degrees C. In mouse striatum, [(3)H]GBR binding...
2.
Roman S, Cusdin F, Fonfria E, Goodwin J, Reeves J, Lappin S, et al.
Br J Pharmacol
. 2009 Oct;
158(6):1513-26.
PMID: 19814727
Background And Purpose: Human and rodent P2X7 receptors exhibit differences in their sensitivity to antagonists. In this study we have cloned and characterized the dog P2X7 receptor to determine if...
3.
Michel A, Clay W, Ng S, Roman S, Thompson K, Condreay J, et al.
Br J Pharmacol
. 2008 Jul;
155(5):738-51.
PMID: 18660826
Background And Purpose: Several P2X(7) receptor antagonists are allosteric inhibitors and exhibit species difference in potency. Furthermore, N(2)-(3,4-difluorophenyl)-N(1)-(2-methyl-5-(1-piperazinylmethyl)phenyl)glycinamide dihydrochloride (GW791343) exhibits negative allosteric effects at the human P2X(7) receptor but...
4.
Michel A, Chambers L, Walter D
Br J Pharmacol
. 2007 Dec;
153(4):737-50.
PMID: 18071294
Background And Purpose: Antagonist effects at the P2X(7) receptor are complex with many behaving in a non-competitive manner. In this study, the effects of N-[2-({2-[(2-hydroxyethyl)amino]ethyl}amino)-5-quinolinyl]-2-tricyclo[3.3.1.1(3,7)]dec-1-ylacetamide (compound-17) and N (2)-(3,4-difluorophenyl)-N (1)-[2-methyl-5-(1-piperazinylmethyl)phenyl]glycinamide...
5.
Fonfria E, Clay W, LEVY D, Goodwin J, Roman S, Smith G, et al.
Br J Pharmacol
. 2007 Nov;
153(3):544-56.
PMID: 18037910
Background And Purpose: The human, rat, and mouse P2X(7) receptors have been previously characterized, and in this study we report the cloning and pharmacological properties of the guinea pig orthologue....
6.
Michel A, Fonfria E
Br J Pharmacol
. 2007 Aug;
152(4):523-37.
PMID: 17700717
Background And Purpose: The P2X(7) receptor exhibits a high degree of plasticity with agonist potency increasing after prolonged receptor activation. In this study we investigated the ability of lipids to...
7.
Michel A, Chambers L, Clay W, Condreay J, Walter D, Chessell I
Br J Pharmacol
. 2007 Mar;
151(1):103-14.
PMID: 17339830
Background And Purpose: The P2X(7) receptor exhibits complex pharmacological properties. In this study, binding of a [(3)H]-labelled P2X(7) receptor antagonist to human P2X(7) receptors has been examined to further understand...
8.
Michel A, Thompson K, Simon J, Boyfield I, Fonfria E, Humphrey P
Br J Pharmacol
. 2006 Oct;
149(7):948-57.
PMID: 17031382
Background: Recent studies have implicated the mitogen activated protein kinase (MAPK) in cellular permeability changes following P2X(7) receptor activation in native tissues. In this study we have further studied the...
9.
Hibell A, Thompson K, Simon J, Xing M, Humphrey P, Michel A
Naunyn Schmiedebergs Arch Pharmacol
. 2001 Jun;
363(6):639-48.
PMID: 11414659
In this study we have expressed recombinant P2X7 receptors in HEK293 cells and examined the reasons for the species- and agonist-dependent differences in the time taken for the closure of...
10.
Michel A, Xing M, Humphrey P
Br J Pharmacol
. 2001 Mar;
132(7):1501-8.
PMID: 11264244
1. 2'-& 3'-O-(4-benzoylbenzoyl)-ATP (BzATP) is the prototypic agonist for P2X(7) receptors. In this study we demonstrate that bovine serum albumin (BSA) can affect the potency of BzATP at P2X receptors....