A D Dobrian
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Explore the profile of A D Dobrian including associated specialties, affiliations and a list of published articles.
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10
Citations
319
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Recent Articles
1.
Dobrian A, Morris M, Taylor-Fishwick D, Holman T, Imai Y, Mirmira R, et al.
Pharmacol Ther
. 2018 Oct;
195:100-110.
PMID: 30347209
12-lipoxygenase (12-LOX) is one of several enzyme isoforms responsible for the metabolism of arachidonic acid and other poly-unsaturated fatty acids to both pro- and anti-inflammatory lipid mediators. Mounting evidence has...
2.
Dobrian A, Hatcher M, Brotman J, Galkina E, Taghavie-Moghadam P, Pei H, et al.
J Endocrinol
. 2015 Aug;
227(1):13-24.
PMID: 26285907
Adipose tissue (AT) inflammation is an emerging factor contributing to cardiovascular disease. STAT4 is a transcription factor expressed in adipocytes and in immune cells and contributes to AT inflammation and...
3.
Imai Y, Dobrian A, Weaver J, Butcher M, Cole B, Galkina E, et al.
Diabetes Obes Metab
. 2013 Sep;
15 Suppl 3:117-29.
PMID: 24003928
Inflammation is an established pathogenic player in insulin resistance, islet demise and atherosclerosis. The complex interactions between cytokines, immune cells and affected tissues result in sustained inflammation in diabetes and...
4.
Dobrian A, Ma Q, Lindsay J, Leone K, Ma K, Coben J, et al.
Am J Physiol Endocrinol Metab
. 2010 Nov;
300(2):E410-21.
PMID: 21081706
Adipose tissue inflammation and reduced pancreatic β-cell function are key issues in the development of cardiovascular disease and progressive metabolic dysfunction in type 2 diabetes mellitus. The aim of this...
5.
Dobrian A, Schriver S, Prewitt R
Hypertension
. 2001 Sep;
38(3):361-6.
PMID: 11566905
One-kidney, 1-clip rats (1K1C) or uninephrectomized controls were treated with either the superoxide dismutase mimetic tempol (0.5 mmol. kg(-1). d(-1)), angiotension type 1 receptor inhibitor losartan (50 mmol. L(-1). kg(-1)....
6.
Wesselman J, Dobrian A, Schriver S, Prewitt R
Hypertension
. 2001 Mar;
37(3):955-60.
PMID: 11244024
Chronic hypertension is associated with remodeling of small arteries. There is evidence that the high pressure itself may cause these structural changes, but the responsible mechanisms are not clearly defined....
7.
Dobrian A, Davies M, Schriver S, Lauterio T, Prewitt R
Hypertension
. 2001 Mar;
37(2 Pt 2):554-60.
PMID: 11230334
The mechanisms underlying the development of hypertension in obesity are not yet fully understood. We recently reported the development of hypertension in a rat model of diet-induced obesity. When Sprague-Dawley...
8.
Dobrian A, Lazar V, Sinescu C, Mincu D, Simionescu M
Atherosclerosis
. 2000 Nov;
153(1):191-201.
PMID: 11058715
Non-insulin-dependent diabetes mellitus (NIDDM) is frequently associated with macroangiopathies and coronary heart diseases. Lipoprotein lipase (LPL), an enzyme known to undergo significant functional alterations in diabetic state, is also a...
9.
Dobrian A, Davies M, Prewitt R, Lauterio T
Hypertension
. 2000 Apr;
35(4):1009-15.
PMID: 10775577
Although obesity is a risk factor for hypertension, the relationship between these 2 conditions is not well understood. Therefore, we examined some parameters of hypertension and cardiovascular disease in a...
10.
Parker S, Dobrian A, Wade S, Prewitt R
Am J Physiol Heart Circ Physiol
. 2000 Feb;
278(2):H613-22.
PMID: 10666094
To separate the role of ANG II from pressure in hypertrophy of the vascular wall in one-kidney, one-clip (1K1C) hypertension, experimental and sham-operated rats were given the AT(1)-receptor antagonist losartan...