A C Nairn
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Explore the profile of A C Nairn including associated specialties, affiliations and a list of published articles.
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220
Citations
8278
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Recent Articles
1.
Bathla S, Datta D, Bolat D, Woo E, Duque A, Arellano J, et al.
bioRxiv
. 2024 Dec;
PMID: 39713378
Tau pathology in sporadic Alzheimer's disease (AD) follows a distinct pattern, beginning in the entorhinal cortex (ERC) and spreading to interconnected brain regions. Early-stage tau pathology, characterized by soluble phosphorylated...
2.
Nagayoshi Y, Chujo T, Hirata S, Nakatsuka H, Chen C, Takakura M, et al.
Sci Adv
. 2021 Mar;
7(13).
PMID: 33771871
() gene has been implicated in X-linked intellectual disability (XLID), but the molecular pathogenesis is unknown. We show that Ftsj1 is responsible for 2'--methylation of 11 species of cytosolic transfer...
3.
Xu J, Hartley B, Kurup P, Phillips A, Topol A, Xu M, et al.
Mol Psychiatry
. 2016 Oct;
23(2):271-281.
PMID: 27752082
The brain-specific tyrosine phosphatase, STEP (STriatal-Enriched protein tyrosine Phosphatase) is an important regulator of synaptic function. STEP normally opposes synaptic strengthening by increasing N-methyl D-aspartate glutamate receptor (NMDAR) internalization through...
4.
Glausier J, Maddox M, Hemmings Jr H, Nairn A, Greengard P, Muly E
Neuroscience
. 2010 Feb;
167(2):428-38.
PMID: 20156529
The actions of dopamine D1 family receptors (D1R) depend upon a signal transduction cascade that modulates the phosphorylation state of important effector proteins, such as glutamate receptors and ion channels....
5.
Zhang Y, Svenningsson P, Picetti R, Schlussman S, Nairn A, Ho A, et al.
J Neurosci
. 2006 Mar;
26(10):2645-51.
PMID: 16525043
The reinforcing effect of cocaine is associated with increases in dopamine in the striatum. The phosphoprotein DARPP-32 (dopamine- and cAMP-regulated phosphoprotein) has been shown to mediate the intracellular events after...
6.
Maus M, Torrens Y, Gauchy C, Bretin S, Nairn A, Glowinski J, et al.
J Neurochem
. 2006 Jan;
96(3):815-24.
PMID: 16405506
Cerebral ischaemia is associated with brain damage and inhibition of neuronal protein synthesis. A deficit in neuronal metabolism and altered excitatory amino acid release may both contribute to those phenomena....
7.
Belelovsky K, Elkobi A, Kaphzan H, Nairn A, Rosenblum K
Eur J Neurosci
. 2005 Nov;
22(10):2560-8.
PMID: 16307598
In a variety of species memory consolidation following different learning paradigms has been shown to be dependent on protein synthesis. However, it is not known whether modulation of protein synthesis...
8.
Vergani P, Basso C, Mense M, Nairn A, Gadsby D
Biochem Soc Trans
. 2005 Oct;
33(Pt 5):1003-7.
PMID: 16246032
Unique among ABC (ATP-binding cassette) protein family members, CFTR (cystic fibrosis transmembrane conductance regulator), also termed ABCC7, encoded by the gene mutated in cystic fibrosis patients, functions as an ion...
9.
Rakhilin S, Olson P, Nishi A, Starkova N, Fienberg A, Nairn A, et al.
Science
. 2004 Oct;
306(5696):698-701.
PMID: 15499021
Calmodulin (CaM) is a major effector for the intracellular actions of Ca2+ in nearly all cell types. We identified a CaM-binding protein, designated regulator of calmodulin signaling (RCS). G protein-coupled...
10.
Chotiner J, Khorasani H, Nairn A, ODell T, Watson J
Neuroscience
. 2003 Feb;
116(3):743-52.
PMID: 12573716
The persistent maintenance of long-term potentiation requires both messenger RNA and protein synthesis. While there is mounting evidence for an active role of protein synthesis in hippocampal long-term potentiation, the...