A C Loweth
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Explore the profile of A C Loweth including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
141
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Recent Articles
1.
WATSON D, Loweth A
Br J Biomed Sci
. 2010 Jan;
66(4):208-15.
PMID: 20095132
The loss of beta-cell mass consequential to the activation of pro-apoptotic signalling events is increasingly recognised as a causal and committed stage in the development of autoimmune, type 1, diabetes...
2.
Trigwell S, Radford P, Page S, Loweth A, James R, Morgan N, et al.
Clin Exp Immunol
. 2001 Nov;
126(2):242-9.
PMID: 11703367
The generation of an autoimmune response against islet beta-cells is central to the pathogenesis of type 1 diabetes mellitus, and this response is driven by the stimulation of autoreactive lymphocytes...
3.
Loweth A, Watts K, McBain S, Williams G, Scarpello J, Morgan N
Diabetes Obes Metab
. 2001 Feb;
2(1):57-60.
PMID: 11220355
There is increasing evidence that inappropriate induction of apoptosis in pancreatic beta-cells may precede the development of type 1 diabetes in animal models and in man. One mechanism by which...
4.
5.
Loweth A, Williams G, James R, Scarpello J, Morgan N
Diabetes
. 1998 May;
47(5):727-32.
PMID: 9588443
IDDM results from a progressive loss of pancreatic beta-cells that, in humans, may be triggered by a combination of genetic and environmental factors. Recently, attention has been focused on the...
6.
Loweth A, Williams G, Scarpello J, Morgan N
FEBS Lett
. 1997 Jan;
400(3):285-8.
PMID: 9009215
Intracellular production of nitric oxide (NO) is thought to mediate the pancreatic B-cell-directed cytotoxicity of cytokines in insulin-dependent diabetes mellitus, and recent evidence has indicated that this may involve induction...
7.
Di Matteo M, Loweth A, Thomas S, Mabley J, Morgan N, Thorpe J, et al.
Apoptosis
. 1997 Jan;
2(2):164-77.
PMID: 14646551
We have shown that nitric oxide treatment for 30-90 min causes inhibition of insulin secretion, DNA damage and disturbs sub-cellular organization in rat and human islets of Langerhans and HIT-T15...
8.
Loweth A, Williams G, Scarpello J, Morgan N
Exp Cell Res
. 1996 Nov;
229(1):69-76.
PMID: 8940250
Recent studies have provided evidence that apoptosis of pancreatic beta-cells is important in the early etiology of both type I and type II diabetes mellitus. The mechanisms responsible for induction...
9.
Loweth A, Scarpello J, Morgan N
Biochem Biophys Res Commun
. 1996 Jan;
218(2):423-7.
PMID: 8561771
In pancreatic beta-cells, arachidonic acid accumulation results primarily from phospholipid hydrolysis by phospholipase A2, and activation of this enzyme has been shown to accompany glucose-induced insulin secretion. Inhibitors of phospholipase...
10.
Loweth A, Scarpello J, Morgan N
Mol Cell Endocrinol
. 1995 Aug;
112(2):177-83.
PMID: 7489821
The expression of different isoforms of phospholipase A2 in human and rat islets of Langerhans and in the clonal B-cell lines, HIT-T15 and RINm5F has been investigated, using polyclonal antisera...