A C Hooker
Overview
Explore the profile of A C Hooker including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
267
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0
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Recent Articles
1.
Brekkan A, Jonsson S, Karlsson M, Hooker A
J Pharmacokinet Pharmacodyn
. 2018 Jun;
45(4):637-647.
PMID: 29948794
Monoclonal antibodies against soluble targets are often rich and include the sampling of multiple analytes over a lengthy period of time. Predictive models built on data obtained in such studies...
2.
Musuamba F, Manolis E, Holford N, Cheung S, Friberg L, Ogungbenro K, et al.
CPT Pharmacometrics Syst Pharmacol
. 2017 Jul;
6(7):418-429.
PMID: 28722322
Inadequate dose selection for confirmatory trials is currently still one of the most challenging issues in drug development, as illustrated by high rates of late-stage attritions in clinical development and...
3.
Nguyen T, Mouksassi M, Holford N, Al-Huniti N, Freedman I, Hooker A, et al.
CPT Pharmacometrics Syst Pharmacol
. 2016 Nov;
6(2):87-109.
PMID: 27884052
This article represents the first in a series of tutorials on model evaluation in nonlinear mixed effect models (NLMEMs), from the International Society of Pharmacometrics (ISoP) Model Evaluation Group. Numerous...
4.
Swat M, Moodie S, Wimalaratne S, Kristensen N, Lavielle M, Mari A, et al.
CPT Pharmacometrics Syst Pharmacol
. 2015 Jul;
4(6):316-9.
PMID: 26225259
The lack of a common exchange format for mathematical models in pharmacometrics has been a long-standing problem. Such a format has the potential to increase productivity and analysis quality, simplify...
5.
Valitalo P, Ranta V, Hooker A, Kokki M, Kokki H
Acta Anaesthesiol Scand
. 2014 Jan;
58(2):143-56.
PMID: 24383522
Population pharmacometric modeling is used to explain both population trends as well as the sources and magnitude of variability in pharmacokinetic and pharmacodynamics data; the later, in part, by taking...
6.
Russu A, Marostica E, De Nicolao G, Hooker A, Poggesi I, Gomeni R, et al.
Clin Pharmacol Ther
. 2012 Apr;
91(5):863-71.
PMID: 22472989
Many difficulties may arise during the modeling of the time course of Hamilton Rating Scale for Depression (HAM D)scores in clinical trials for the evaluation of antidepressant drugs: (i) flexible...
7.
Zamuner S, Di Iorio V, Nyberg J, Gunn R, Cunningham V, Gomeni R, et al.
Clin Pharmacol Ther
. 2010 Mar;
87(5):563-71.
PMID: 20336064
Positron emission tomography (PET) is an imaging technique that is used to investigate ligand-receptor binding in the living brain and to determine the time course of plasma concentration/receptor occupancy (RO)....
8.
Hooker A, Ten Tije A, Carducci M, Weber J, Garrett-Mayer E, Gelderblom H, et al.
Clin Pharmacol Ther
. 2008 Jan;
84(1):111-8.
PMID: 18183036
The relationship between cytochrome P4503A4 (CYP3A4) activity and docetaxel clearance in patients with varying degrees of liver function (LF) was evaluated. Docetaxel 40, 50, or 75 mg/m(2) was administered to...