A Blackham
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Explore the profile of A Blackham including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
123
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Recent Articles
1.
Liu Y, Jackson D, Blackham A, Leff P
Eur J Pharmacol
. 1996 May;
304(1-3):117-22.
PMID: 8813592
We examined the interactions of prostaglandin D2, BW245C ((+/-)-5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl)-hydantoin) a selective DP receptor agonist and BW A868C ((+/-)-3-benzyl-5-(6-carboxyhexyl)-1-(2-cyclohexyl-2- hydroxyethylamino)-hydantoin) a selective DP receptor antagonist on Cl- secretion using dog isolated...
2.
Liu Y, Jackson D, Blackham A
Eur J Pharmacol
. 1996 May;
303(3):187-92.
PMID: 8813566
The effects of the selective prostaglandin DP receptor antagonist BW A868C ((+/-)-3-benzyl-5-(6-carboxyhexyl)-1-(2-cyclohexyl-2-hydroxyethylamin o)- hydantoin), 3.0 nM to 0.3 microM) were examined against prostaglandin D2 and BW245C ((+/-)-5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl)-hydantoin)-in duced smooth muscle...
3.
Kind C, Blackham A, Morris C
Ann Rheum Dis
. 1992 Nov;
51(11):1237-41.
PMID: 1466600
The effect of intravenously infused iron-dextran (Imferon) on the progression of antigen induced monarticular arthritis in rabbits was studied. A rapid deposition of iron and apoferritin in the synovia of...
4.
Blackham A, Griffiths R
Clin Exp Immunol
. 1991 Nov;
86(2):224-8.
PMID: 1718639
FK506 and cyclosporin A inhibited the development of antigen-induced arthritis in the rat and rabbit. FK506 was five times more potent than cyclosporin A in the rat and approximately 20...
5.
Griffiths R, Li S, Wood B, Blackham A
Agents Actions
. 1991 Mar;
32(3-4):312-20.
PMID: 1650524
Intraperitoneal and intra-articular (knee joint) injection of zymosan in the rat caused two phases of increased vascular permeability, a rapid increase (0.25-0.5 h) and a secondary increase (2-3 h) which...
6.
van Delft J, van Haeringen N, Barthen E, Van Best J, Blackham A
Ophthalmic Res
. 1991 Jan;
23(6):330-4.
PMID: 1803314
Antagonists of leukotriene D4 (LTD4), 3-[7-(2-n-propyl-3-hydroxy-4-acetyl- phenoxy)-propoxy-2-methyl-3,4-dihydro-4-8-n-propyl-2H-1-benzopyran- 2-yl]-propionic acid (SC-39070) and 7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxy- propoxy]-4-methyl- 2-oxo-2H-1-benzopyran-3-acetic acid (FPL-60319) were locally administered to eyes of rabbits with immunogenic keratitis. The period of circular...
7.
Blackham A, Griffiths R, Hallam C, Mann J, MITCHELL P, Norris A, et al.
Agents Actions
. 1990 Jun;
30(3-4):432-42.
PMID: 2117338
FLP 62064 [N-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-3-amine] is a dual inhibitor of prostaglandin synthetase and 5-lipoxygenase. The compound had anti-inflammatory activity in vivo in a number of models. It inhibited peritoneal inflammation induced by...
8.
Griffiths R, Wood B, Li S, Blackham A
Skin Pharmacol
. 1989 Jan;
2(1):30-7.
PMID: 2560651
Ciclosporin is clinically effective in a variety of inflammatory skin diseases. We have therefore studied the effects of the drug on cutaneous inflammation in mice. Ciclosporin inhibited the inflammatory response...
9.
Griffiths R, Wood B, Li S, Blackham A
Agents Actions
. 1988 Dec;
25(3-4):344-51.
PMID: 3146216
Topical application of TPA to mouse skin causes oedema (2-6 h) neutrophil influx (3-24 h) and epidermal cell proliferation (24-48 h). Topical application of a cyclooxygenase inhibitor (indomethacin) dual cyclooxygenase...
10.
Blackham A, Woods F
J Pharmacol Methods
. 1986 Feb;
15(1):77-85.
PMID: 3081764
Intraperitoneal injection of washed, preformed ovalbumin/anti-ovalbumin immune complexes caused the production of slow-reacting substance (SRS), prostaglandin E2, 6 keto prostaglandin Fla, vascular permeability (measured as extravazation of pontamine sky blue...