A B Shapiro
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Explore the profile of A B Shapiro including associated specialties, affiliations and a list of published articles.
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36
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723
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Recent Articles
1.
Bychkova A, Sorokina O, Kovarskii A, Shapiro A, Leonova V, Rozenfeld M
Biofizika
. 2010 Oct;
55(4):605-11.
PMID: 20968070
The interaction between fibrinogen and magnetite nanoparticles in solution has been studied by the methods of spin labeling, ferromagnetic resonance, dynamic and Rayleigh light scattering. It was shown that protein...
2.
Lam F, Liu R, Lu P, Shapiro A, Renoir J, Sharom F, et al.
J Neurochem
. 2001 Feb;
76(4):1121-8.
PMID: 11181832
A large body of evidence suggests that an increase in the brain beta-amyloid (Abeta) burden contributes to the etiology of Alzheimer's disease (AD). Much is now known about the intracellular...
3.
Sonveaux N, Vigano C, Shapiro A, Ling V, Ruysschaert J
J Biol Chem
. 1999 Jun;
274(25):17649-54.
PMID: 10364203
Ligand-dependent changes in accessibility of purified P-glycoprotein, functionally reconstituted in liposomes, were investigated by fluorescence measurements. Trp quenching experiments provided evidence that P-glycoprotein adopts different tertiary structures upon binding of...
4.
Shapiro A, Fox K, Lam P, Ling V
Eur J Biochem
. 1999 Mar;
259(3):841-50.
PMID: 10092872
P-glycoprotein is a plasma membrane protein of mammalian cells that confers multidrug resistance by acting as a broad-specificity, ATP-dependent efflux transporter of diverse lipophilic neutral or cationic compounds. Previously, we...
5.
Shapiro A, Ling V
Acta Physiol Scand Suppl
. 1998 Oct;
643:227-34.
PMID: 9789565
Experiments with purified P-glycoprotein (Pgp) reconstituted into proteoliposomes have conclusively demonstrated that Pgp is an ATP-dependent drug transporter. Detailed biochemical analyses of drug transport by Pgp are beginning to yield...
6.
Shapiro A, Ling V
Eur J Biochem
. 1998 Jul;
254(1):189-93.
PMID: 9652413
In order to describe the transport mechanism of P-glycoprotein, it is essential to know the coupling ratio, i.e. the moles substrate transported/mole ATP hydrolyzed. P-glycoprotein couples ATP hydrolysis at two...
7.
Shapiro A, Ling V
Eur J Biochem
. 1998 Jul;
254(1):181-8.
PMID: 9652412
P-glycoprotein is an ATP-dependent transporter of an extremely wide variety of lipophilic compounds. We showed previously [Shapiro, A. B. & Ling, V. (1997a) Eur. J. Biochem. 250, 130-137] that P-glycoprotein...
8.
Shapiro A, Fox K, Lee P, Yang Y, Ling V
Int J Cancer
. 1998 Jun;
76(6):857-64.
PMID: 9626353
Efflux of chemotherapy drugs by P-glycoprotein (P-gp) at the plasma membrane is thought to be a major cause of cancer multidrug resistance. In this report, we show by flow cytometry...
9.
Shapiro A, Ling V
Eur J Biochem
. 1998 Feb;
250(1):130-7.
PMID: 9432000
In this paper, we show that P-glycoprotein contains two distinct sites for drug binding and transport, and that, unexpectedly, these sites interact in a positively cooperative manner. The kinetics of...
10.
Shapiro A, Ling V
Eur J Biochem
. 1998 Feb;
250(1):122-9.
PMID: 9431999
P-glycoprotein is an ATP-dependent plasma membrane multidrug transporter of broad specificity. A common chemical property of its substrates is that all are lipophilic. Using Hoechst 33342 as the substrate, we...