A A Humbles
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Explore the profile of A A Humbles including associated specialties, affiliations and a list of published articles.
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8
Citations
449
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Recent Articles
1.
Chu D, Mohammed-Ali Z, Jimenez-Saiz R, Walker T, Goncharova S, Llop-Guevara A, et al.
Mucosal Immunol
. 2014 May;
7(6):1395-404.
PMID: 24781052
Intestinal T helper type 2 (Th2) immunity in food allergy results in IgG1 and IgE production, and antigen re-exposure elicits responses such as anaphylaxis and eosinophilic inflammation. Although interleukin-4 (IL-4)...
2.
Al-Garawi A, Fattouh R, Botelho F, Walker T, Goncharova S, Moore C, et al.
Mucosal Immunol
. 2011 Sep;
4(6):682-94.
PMID: 21881572
The origins of allergic asthma, particularly in infancy, remain obscure. Respiratory viral infections and allergen sensitization in early life have been associated with asthma in young children. However, a causal...
3.
Botelho F, Nikota J, Bauer C, Davis N, Cohen E, Anderson I, et al.
Eur Respir J
. 2011 Mar;
38(2):285-94.
PMID: 21436349
We investigated the role of granulocyte-macrophage colony-stimulating factor (GM-CSF) in a subchronic exposure model of cigarette smoke (CS)-induced inflammation using antibodies directed against GM-CSF or the GM-CSF receptor (GM-CSFR) α-chain....
4.
Humbles A, Lu B, Nilsson C, Lilly C, Israel E, Fujiwara Y, et al.
Nature
. 2000 Sep;
406(6799):998-1001.
PMID: 10984054
Asthma is a chronic inflammatory disease of the airways and lung mucosa with a strong correlation to atopy and acquired (IgE) immunity. However, many features of bronchial asthma, such as...
5.
BOZZA M, Satoskar A, Lin G, Lu B, Humbles A, Gerard C, et al.
J Exp Med
. 1999 Jan;
189(2):341-6.
PMID: 9892616
To study the biologic role of migration inhibitory factor (MIF), a pleiotropic cytokine, we generated a mouse strain lacking MIF by gene targeting in embryonic stem cells. Analysis of the...
6.
Humbles A, Conroy D, Marleau S, Rankin S, Palframan R, Proudfoot A, et al.
J Exp Med
. 1997 Aug;
186(4):601-12.
PMID: 9254658
Challenge of the airways of sensitized guinea pigs with aerosolized ovalbumin resulted in an early phase of microvascular protein leakage and a delayed phase of eosinophil accumulation in the airway...
7.
Conroy D, Humbles A, Rankin S, Palframan R, Collins P, Jose P, et al.
Mem Inst Oswaldo Cruz
. 1997 Jan;
92 Suppl 2:183-91.
PMID: 9698931
Blood eosinophilia and tissue infiltration by eosinophils are frequently observed in allergic inflammation and parasitic infections. This selective accumulation of eosinophils suggested the existence of endogenous eosinophil-selective chemoattractants. We have...
8.
Nials A, Ball D, Butchers P, Coleman R, Humbles A, Johnson M, et al.
Eur J Pharmacol
. 1994 Jan;
251(2-3):127-35.
PMID: 8149969
Formoterol, like salbutamol and salmeterol, relaxed isolated preparations of guinea-pig trachea and human bronchus, and inhibited antigen-induced mediator release from human lung fragments in a concentration-related fashion. In each case,...