Fungal Lethality, Binding, and Cytotoxicity of Syringomycin-E

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1999 Jan 30

PMID 9925536

Citations 6

Authors

A J De Lucca

T J Jacks

J Takemoto

B Vinyard

J Peter

E Navarro

T J Walsh

Affiliations

Soon will be listed here.

Abstract

Syringomycin-E (SE) was significantly lethal to Aspergillus and Fusarium species at between 1.9 and 7.8 micrograms/ml. SE complexed with the following fungal wall constituents (in order of binding): beta-1,3-glucan > chitin > mannan > ergosterol = cholesterol. Cytotoxicity in HeLa cells was proportional to the SE concentration, while the amount required for cytotoxicity was 3 to 20 times that needed to kill 95% of the fungi tested.

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